中华皮肤科杂志

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胎传梅毒危险因素的病例对照研究

周华, 潘鹏, 洪福昌, 陈钢, 杨帆, 林丽君, 蔡于茂   

  1. 深圳市慢性病防治院皮肤病研究所 518020
  • 收稿日期:2006-03-30 出版日期:2006-04-15 发布日期:2006-04-15
  • 基金资助:
    深圳市科技基金(200404004);深圳市重点医学专科建设基金;深圳市预防与控制梅毒母婴传播项目基金资助

Risk factors in association with congenital syphilis:a case control study

ZHOU Hua, PAN Peng, HONG Fu-chang, CHEN Gang, YANG Fan, LIN Li-jun, CAI Yu-mao   

  1. Institute of Dermato-venereology, Shenzhen Chronic Disease Hospital, Shenzhen 518020, China
  • Received:2006-03-30 Online:2006-04-15 Published:2006-04-15

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摘要： 目的 探讨胎传梅毒的危险因素,为完善深圳市梅毒母婴传播控制项目策略提供参考.方法 对51例明确诊断胎传梅毒者和320例明确排除胎传梅毒诊断者进行巢式病例对照研究,采用单因素Logistic和非条件Logistic回归分析.结果 单因素分析结果表明,母亲的年龄、住址、文化程度、治疗开始孕周、确诊时甲苯胺红不加热血清试验滴度及父亲的文化程度、职业和多性伴史与胎传梅毒的发生有统计学意义关联.多因素分析中,非条件Logistic回归分析发现4个变量:母亲年龄、父亲的文化程度、母亲治疗开始时孕周及确诊时母亲甲苯胺红不加热血清试验滴度对胎传梅毒患病率产生影响.结论 早期发现和治疗妊娠梅毒是降低胎传梅毒发生的重要措施.

关键词: 梅毒,先天性, 危险因素, 病例对照研究

Abstract: Objective To investigate the risk factors in association with congenital syphilis,in order to provide a basis for further improvement of the ongoing Prevention of Mother to Child Syphilis Transmission Project in Shenzhen.Methods A nested case-control study was designed in neonates with risk of congenital syphilis.The case group included 51 neonates with congenital syphilis,and the control group included 320 neonates without the disease.Results The risk factors in association with congenital syphilis were mother's age,residence,education level,weeks of gestation at time of starting standardized treatment,mother's TRUST titer at time of diagnosis;and also father's education level,occupation and history of multiple sex partners,as showed with univariate logistic regression analysis.After adjusted with multivariate unconditional logistic regression analysis,4 independent risk factors were found,namely,mother's age,father's education level,weeks of gestation at time of starting standardized treatment,and mother's TRUST titer at time of diagnosis.Conclusions Risk factors in association with congenital syphilis are identified,which provide important clues for effective prevention of congenital syphilis.

Key words: Syphilis,congenital, Risk factors, Case-control studies