暗娼人群DC-SIGN及DC-SIGNR基因多态性初步研究

中华皮肤科杂志 ›› 2006, Vol. 39 ›› Issue (11): 645-647.

暗娼人群DC-SIGN及DC-SIGNR基因多态性初步研究

王峰, 洪福昌, 王辉, 蓝丽娜, Chunhui Wang, 熊礼宽, 肖昕, 周伯平, 周华, Tuofu Zhu

1. 深圳市慢性病防治院;
2. 深圳市东湖医院;
3. 暨南大学

收稿日期:2006-01-23 出版日期:2006-11-15 发布日期:2006-11-15
通讯作者: 周华, email:hua.zhou@263.net E-mail:email;hua.zhou@263.net
基金资助:
美国华盛顿大学CFAR基金[3 P30 AI27757-18S3];深圳市2005科技计划重点项目(JH200505270384A)

The genetic polymorphisms of DC-SIGN and DC-SIGNR among female sex workers

WANG Feng, HONG Fu-chang, WANG Hui, LAN Li-na, Chunhui Wang, XIONG Li-kuan, XIAO Xin, ZHOU Bo-ping, ZHOU Hua, Tuofu Zhu

Shenzhen Chronic Disease Control Center, Shenzhen 518020, China

Received:2006-01-23 Online:2006-11-15 Published:2006-11-15

摘要/Abstract

摘要： 目的分析中国暗娼人群中DC-SIGN及DC-SIGNR基因多态性的分布,比较不同研究人群等位基因频率分布。方法PCR检测234例HIV阴性暗娼DC-SIGN及DC-SIGNR基因多态性。结果DC-SIGN基因型在234例中发现4例突变杂合子。DC-SIGNR等位基因频率以7次重复最为常见(65.2%),其次为5次重复(18.4%)和9次重复(11.9%),其基因频率分布与国外报道差异有统计学意义。结论DC-SIGN基因具有多态性,而DC-SIGNR基因多态性分布同国外报道比较存在差异。

关键词: DC-SIGN, DC-SIGNR, 多态现象,遗传, 暗娼

Abstract: Objective To determine the genetic polymorphisms of DC-SIGN and DC-SIGNR among HIV negative Chinese female sex workers.Methods The 69 bp tandem repeat numbers in exon 4 of the DC-SIGN and DC-SIGNR were examined by PCR in 234 HIV-1-seronegative female commercial sex workers.Results It was found that 4 of 234 individuals were heterozygous in DC-SIGN.For DC-SIGNR,the allele frequencies were seven times repeated in 65.2%,5 in 18.4%,and 9 in 11.9%.Those patterns of alleles frequencies were significantly different compared with those reported in the Caucasians residing in Europe.Conclusion Polymorphisms of DC-SIGN repeat region seem to be infrequent in Chinese female sex workers and those of DC-SIGNR are different from what reported in other races.

Key words: DC-SIGN, DC-SIGNR, Polymorphism, genetic, Female sex worker

王峰, 洪福昌, 王辉, 蓝丽娜, Chunhui Wang, 熊礼宽, 肖昕, 周伯平, 周华, Tuofu Zhu. 暗娼人群DC-SIGN及DC-SIGNR基因多态性初步研究[J]. 中华皮肤科杂志, 2006, 39(11): 645-647.doi:

WANG Feng, HONG Fu-chang, WANG Hui, LAN Li-na, Chunhui Wang, XIONG Li-kuan, XIAO Xin, ZHOU Bo-ping, ZHOU Hua, Tuofu Zhu. The genetic polymorphisms of DC-SIGN and DC-SIGNR among female sex workers[J]. Chinese Journal of Dermatology, 2006, 39(11): 645-647.doi:

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