中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (1): 23-25.

• 论著 • 上一篇    下一篇

人纤维介素在系统性红斑狼疮患者外周血单一核细胞中的表达及意义

严小枫, 涂亚庭, 林能兴   

  1. 华中科技大学同济医学院附属协和医院皮肤科, 武汉430022
  • 收稿日期:2004-01-27 出版日期:2005-01-15 发布日期:2005-01-15

Expression of HFGL2/Fibroleukin in Peripheral Blood Mononuclear Cell in Patients with Systemic Lupus Erythematosus and Its Clinical Significance

YAN Xiao-feng, TU Ya-ting, LIN Neng-xing   

  1. Department of Dermatology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  • Received:2004-01-27 Online:2005-01-15 Published:2005-01-15

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摘要： 目的 探讨人纤维蛋白原样蛋白/人纤维介素(HFGL2)与SLE中存在的凝血功能障碍之间的关系。方法 采用免疫组化方法检测32例SLE患者和15例正常人外周血单一核细胞(PBMC)中HFGL2蛋白的表达情况,并用高清晰度彩色医学图文分析系统对SLE患者PBMC中HFGL2的表达进行半定量分析。结果 与正常人对照组相比,活动期SLE患者PBMC中HFGL2的表达明显增高,并与疾病活动性呈正相关。结论 PBMC中HFGL2的表达可能与SLE的发病和疾病的活动有关。

关键词: 红斑狼疮,系统性, 人纤维介素, 基因表达

Abstract: Objective To investigate the relationship between procoagulation of HFGL2 and abnormality of coagulation in patients with systemic lupus erythematosus (SLE) by detecting the expression of HFGL2/fibroleukin in peripheral blood mononuclear cell(PBMC) of SLE patients. Methods A polyclonal antibody against HFGL2 was applied to detecting the expression of HFGL2 protein in 32 SLE patients and 15 healthy volunteers by immunohistochemistry. Semi-quantitative measurement of HFGL2 expression in the blood specimen was done with high multiple image analytical system(HMIAS). Results The expression of HFGL2 in PBMC from 23 active SLE patients was significantly higher than that in the controls, which showed a positive correlation with the disease activity. Conclusion The expression of HFGL2 in PBMC is probably correlated with the pathogenesis and disease activity of SLE.

Key words: Lupus erythematosus, Systemic, hfg12 prothrombinase/fibroleukin, gene expression