中华皮肤科杂志 ›› 1993, Vol. 26 ›› Issue (5): 273-275.

• 论著 • 上一篇    下一篇

外用安体舒通、复方安体舒通和过氧苯甲酸治疗痤疮的比较研究

胡兹嘉, 靳培英, 马林, 张怀亮, 路永红, 沈丹蓓, 邵华静   

  1. 中国医学科学院, 中国协和医科大学皮肤病研究所, 南京, 210042
  • 收稿日期:1992-09-08 修回日期:1993-02-01 出版日期:1993-10-15 发布日期:1993-10-15

Comparative Study of Spironolactone, Spironoiactone Composite and Benzoyl Peroxide in the Treatment of Acne Vulgaris

HU Zi-jia, JIN Pei-Ying   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Melical College, Nanjing 210042
  • Received:1992-09-08 Revised:1993-02-01 Online:1993-10-15 Published:1993-10-15

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摘要： 103例寻常痤疮患者随机分为3组,分别外用0.3%安体舒通(SP),复方安体舒通(含1%氯洁霉素SPC),和过载苯甲酞(BP)乳剂,每日2次,疗程6周.双育比较的结果显示:①3组病例的炎症性皮损数于治疗后均明显减少,SP组,SPC组和BP组的有效率分别为73%,83%,和77%.②3组脂溢程度评分均明显下降(P<0.0001).SPC组和BP组FFA/TG比值下降明显(P<0.05),SP组无明显改变.④BP组皮肤刺激作用明显,SP组和SPC组轻微.观察结果表明外用0.3%安体舒通霜治疗痤疮有效.含1%抓洁霉素的复方霜剂疗效优于过氧苯甲酞,副作用小.可推荐于临床应用.

关键词: 痤疮, 联合用药疗法

Abstract: One hundred and three patients with acne vulgaris were randomly divided into three groups in which 0.3% spironolactone (SP) cream,spironolactone Composite cream containing 1% clindamycin (SPC),and 10% benzoyl peroxide (BP)cream were topically used for 6 weeks,respectively.The results of the doublc-blind study showed that: (1) the numbers of inflammatory lesions in the SP,SPC and BP groups were significantly decreased after treatment with the effective rates of 73%,83% and 77%.respectively; (2) the seborrheic scores in all groups were significantly lower than thosc 6eforc treatment (P<0.0001);(3) FFA/TG ratios were significantly decreased in both the SPC and BP groups (P < 0.05),but there was no significant difference observed in the BP group; (4) there was apparent irritation to the skin in the BP group and slight irritation in both the SP and SPC group.It is confirmed that topical application of 0.3%,spironolaclone is effective for the treatment of acne vulgaris,and spironoiactone composite can also be used clinically because it bas good therapcatic effect and less side effect than that of benzoyl peroxde.

Key words: Acne, Combined modality therepy