中华皮肤科杂志 ›› 1993, Vol. 26 ›› Issue (6): 346-348.

• 论著 • 上一篇    下一篇

外用甲氰咪胍与氟嗪酸治疗痤疮的研究

李和莲1, 余敏1, 马林1, 沈永年1, 戴星1, 弓娟琴1, 李婷婷1, 樊天经2   

  1. 1. 中国医学科学院、中国协和医科大学皮肤病研究所, 南京 210042;
    2. 南京人口管理干部学院
  • 收稿日期:1992-12-14 修回日期:1993-03-16 出版日期:1993-12-15 发布日期:1993-12-15

Study of the Effect of Cimetidine and Ofloxacin Cream on Patients with Acne Vulgaris

LI He-Lian1, YU Min1   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042
  • Received:1992-12-14 Revised:1993-03-16 Online:1993-12-15 Published:1993-12-15

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摘要： 报告了2%甲氰咪胍霜与0.75%氟嗪酸霜对寻常痤疮的治疗情况.两组各21例,共治疗4周,双盲对照观察疗效.结果表明治疗非炎症性皮损时甲氰咪胍优于优于氟嗪酸(x2检验,P<0.05);治疗炎症性皮损氟嗪酸疗效优于甲叙咪胍(x2检验,P<0.05).它们的复方制剂〔复方甲咪肌)与10%过氧化苯甲酞以同样方法治疗痊疮患者各53例.结果表明复方甲氰咪肌的总显效率优于过氧化苯甲酰(x2检验,P<0.05).又观察了甲氰眯胍对20例痊疮患者皮脂溢出率(SER)的影响情况,并与20例健康成人进行了年龄、性别配对的皮脂溢出率对比观察.结果表明座疮患者的皮脂溢出率是健康成人的2倍,治疗后下降约44%.上述结果提示复方甲氰咪肌霜是治疗寻常痊疮的有效药物.

关键词: 痤疮, 西咪替丁, 氟嗪酸, 过氧化苯甲酚

Abstract: This article reports the eliect of 2% cimetidine cream and 0.75% ofloxacin cream on patients with acne volgaris.A double blind randomized clinical trial was performed on 21 pairs of acne cases for 4 weeks.The results revealed that the clinical effects of cimetidine are better than those of ofloxacin in treating non-inflammatory lesions(P<0.05),and the clinical effects of ofloxacine are better than those of cimetidinc in treating inflammatory lesions(P<0.05).A comparative study was conducted in 53 pairs of acne cases treated by cimetidine co cream(2% cimetidine and 0.75% ofoxacin) and 10% benzoyl peroxide cream.The results revealed that the total good etTective rate of cimetidine co cream is better than that of benzoyl peroxide cream(P<0.05).besides,a comparative study was conducted among 20 acne cases and 20 healthp controls matched with age and sex for the observation on the effect of sebum excretion rate(SER) of acne cases treated by cimetidine Cream.The results revealed that the SER of acne cases before treatment is about 2 times than that of healthy controls,and after treatment the SER of acne cases decreased about 44%.These results suggest that cimetidine co cream is an effective drug for treating acne vulgaris.

Key words: Acne, Cimetidine Ofloxacin, Benzoyl perovide