中华皮肤科杂志 ›› 2013, Vol. 46 ›› Issue (1): 56-57.

• 研究报道 • 上一篇    下一篇

生长期毛发松动综合征二例毛发形态学观察

陈琢1,李中明2,范卫新3   

  1. 1. 上海交通大学医学院附属上海儿童医学中心
    2.
    3. 南京医科大学第一附属医院皮肤科
  • 收稿日期:2012-01-10 修回日期:2012-07-26 出版日期:2013-01-15 发布日期:2013-01-01
  • 通讯作者: 范卫新 E-mail:fanweixi@medmail.com.cn

Morphological observation of hairs in two patients with loose anagen hair syndrome

  • Received:2012-01-10 Revised:2012-07-26 Online:2013-01-15 Published:2013-01-01

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摘要： 目的 探讨2例生长期毛发松动综合征患者毛发形态。方法 普通显微镜、扫描电镜、透射电镜观察患者的毛干及毛囊。结果 光学显微镜下见毛球变形，发干扭曲、损伤、断裂，远端明显尖细。扫描电镜下见患者毛球变形扭曲，毛护膜边缘呈波浪状等。透射电镜下见病变主要在内毛根鞘，内外毛根鞘细胞均见多数空泡化改变，细胞间黏附减低，桥粒结构减少或消失等。结论 生长期毛发松动综合征患者病变主要在内毛根鞘。

关键词: 毛发松动综合征, 生长期, 显微镜检查，电子

Abstract: CHEN Zhuo*, LI Zhong-ming, FAN Wei-xin. *Department of Dermatology, Changhai Hospital, Shanghai 200433, China Corresponding author: FAN Wei-xin, Email：fanweixin@medmail.com.cn 【Abstract】 Objective To observe the morphological changes of hairs in two patients with loose anagen hair syndrome. Methods Light microscopy, scanning electron microscopy and transmission electron microscopy were used to observe the morphology of hair shaft and follicles from two patients, including a 3-year-old girl child and her mother, with loose anagen hair syndrome. Results Light microscopy revealed that hair bulb was deformed, hair shaft was distorted, damaged, and even disrupted, and hairs tapered in diameter at their distal end. Scanning electron microscopy showed deformed or distorted hair shaft and wave-like edge of hair cuticles. Trans- mission electron microscopy revealed that pathological changes were mainly localized in the inner root sheath with vacuolization in both inner and outer root sheath cells. Intercellular adhesion was weak with a decrease or disappearance of desmosomes. Conclusion The pathological changes of hairs are mainly localized in the inner root sheath in patients with loose anagen hair syndrome.