中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (2): 86-88,128.

• 实验研究 • 上一篇    下一篇

不同免疫状态下的白念珠菌对小鼠肠粘膜的粘附及影响

郭宁如, 沈永年, 吕桂霞, 吴绍熙   

  1. 中国协和医科大学皮肤病研究所, 南京, 210042
  • 收稿日期:1993-01-07 修回日期:1993-04-14 出版日期:1994-04-15 发布日期:1994-04-15
  • 基金资助:
    国家自然科学基金资助项目

Adherence of Candida Albicans to Murine Intestinal Mucosa in Various Immune Status and its Influence

GUO Ning-Ru, SHENG Yong-Nian, LÜ Gui-Xia   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042
  • Received:1993-01-07 Revised:1993-04-14 Online:1994-04-15 Published:1994-04-15

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摘要： 以不同剂量白念珠菌(白念)经日攻击健康小鼠,其对肠粘膜的粘附量与菌量成正比;地塞米松、氨甲蝶呤、四环素等均可促进粘附并向内脏播散甚或致死,提示肠道携带白念是免疫低下宿主并系统感染的重要储存灶。几丁质可降低粘附,可考虑作为预防措施之一。

关键词: 粘附, 白念珠菌

Abstract: Challenged with various doses of Candida albicans by oral intragastric route colonization of Candida albicans on the gastrointestinal (GI) tract was observed.The results showed that the percentage of Candida albicans adherent to the intestinal mucose was proportional to the doses of fungi.Dexamethasone, methotrexate and tetracycline could all increase the adherence of Candida to the GI mucosa, and partly disseminated to other organs leading the mice to death.It suggests that colonization of Candida on GI is an important reservior in immunocompromised hosts.Chitins have the effect to inhibit the adherence and can be considered as a means for prophylaxis.

Key words: Candida albicans, Adherence