中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (2): 80-82,127.

• 实验研究 • 上一篇    下一篇

国产氟康唑抗真菌药效学研究

吴绍熙, 郭宁如, 沈永年, 吕桂霞   

  1. 中国医学科学院、中国协和医科大学皮肤病研究所, 南京, 210042
  • 收稿日期:1993-01-13 修回日期:1993-04-28 出版日期:1994-04-15 发布日期:1994-04-15

Study on Antifungal Effects of Domestic Fluconazole

WU Shao-Xi, GUO Ning-Ru, SHEN Yong-Nian   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042
  • Received:1993-01-13 Revised:1993-04-28 Online:1994-04-15 Published:1994-04-15

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摘要： 对国产氟康唑作体内外药效学研究中发现不论在体外或体内均具有较好的广谱抗真菌作用。体外对31株白念珠菌(白念MIC为0.8～200mg/L)、24株新型隐球菌(新隐MIC为2.24～35.4mg/L)及部份皮癣菌等均有较好的抑菌作用,其MIC范围及MIC50、MIC90的结果均与国外同类制品(0.2～>100mg/L及3.13～12.5mg/L)相似,且对国外尚未报道的马尔尼菲青霉菌均有一定抑菌作用。体内对白念与新型隐球菌脑膜炎的50%致死保护量(ED50)为0.057～0.949mg/kg,与国外同类产品相当或更佳(0.08～1.25mg/kg).提示国产氟康唑与进口制品相似,可用于人类的系统性真菌感染,尤其是对难治的新型隐球菌脑膜炎可获得较好疗效。

关键词: 氟康唑, 新型隐球菌, 白念珠菌

Abstract: The antifungal effects of domestic fluconazoie were studied both in vitro and in vivo.In vitro, the antifungal action of fulconazole to 31 strains of Candida albicans (MIC 0.8-200 mg/L), 24 strains of Cryptococcus neoformans (MIC 2.24 -35.4mg/ L)and some dermatophytes showed good fungistatic action.The MIC, MIC50 and MIC90 are similar to those of fluconazole (0.2~> 100mg/L, 3.13~12.5ing/L).The antifungal effect to Penicillium marneffei is also very good (MIC 3.125mg/L), which is the preliminary report in the literature.In vivo, the ED50 of fluconazole to meningitis caused by Candida albicans and Cryptococcus neoformans was 0.057 pew 0.949mg/kg which reveals even more effective than fluconazole.These results show that the antifungal effects of domestic fluconazole are more or less similar to those of imported fluconazole.it suggests that fluconazole may be effective for the treatment of human systemic fungal infections especially for the treatment of obstinate cryptococcal meningitis.

Key words: Fluconazole, Cryptococcus neoformans, Candida albicans