中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (3): 157-159.

• 论著 • 上一篇    下一篇

毛囊闭锁性三联征一例及家系分析

徐薇, 赵俊英, 赵绘, 顾菲, 黄笑鸣   

  1. 首都医科大学附属北京友谊医院皮肤科 100050
  • 收稿日期:2004-01-08 出版日期:2005-03-15 发布日期:2005-03-15

Follicular Occlusion Triad:a Case Report and Pedigree Analysis

XU Wei, ZHAO Jun-ying, ZHAO Hui, GU Fei, HUANG Xiao-ming   

  1. Department of Dermatology, Beijing Friendship Hospital Affiliated to Capital University of Medical Sciences, Beijing 100050, China
  • Received:2004-01-08 Online:2005-03-15 Published:2005-03-15

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摘要： 目的 探讨毛囊闭锁性三联征的临床和遗传学特点。方法 对1例毛囊闭锁性三联征继发鳞状细胞癌的特殊病例,在临床检查的基础上,进行了家系调查和系谱分析。结果 此家系共有13例,于20岁左右发病,先证者临床特点及实验室检查符合毛囊闭锁性三联征的诊断。结论 遗传因素是不可忽视的主要因素,本病可能为常染色体显性遗传病。

关键词: 毛囊闭锁性三联征, 癌,鳞状细胞, 谱系, 皮肤疾病,遗传性

Abstract: Objective To study the clinical features of follicular occlusion triad,and whether it is a hereditary disease.Methods Based on the clinical examination of a case who developed squamous cell carcinoma secondary to follicular occlusion triad,the pedigree of the patient was surveyed and analyzed.Results There were a total of thirteen patients in this pedigree,the age of onset was about 20 years old.The clinical features and laboratory examination of the proband was consistent with follicular occlusion triad.Conclusions Hereditary factor is important in the pathogenesis in follicular occlusion triad,and the disease maybe an autosomal dominant inherited disease.

Key words: Follicular occlusion triad, Carcinoma,squamous cell, Pedigree, Skin diseases,genetic