中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (4): 218-220,269.

• 论著 • 上一篇    下一篇

萱草花提取液及表皮生长因子对人真皮成纤维细胞增殖的作用

何成雄   

  1. 福建省皮肤病性病防治院, 福州, 350009
  • 收稿日期:1993-08-06 修回日期:1993-12-01 出版日期:1994-08-15 发布日期:1994-08-15
  • 基金资助:
    中丹交换学者奖学金研究课题

Effects of Extract from Hemerocallis Citrina Barroni (EHCB) and Epidermal Growth Factor (EGF) on Human Dermal Fibroblast Proliferation

HE Cheng-Xiong   

  1. Fujian Provincial Hospital of Dermatovenereology, Fuzhou 350009
  • Received:1993-08-06 Revised:1993-12-01 Online:1994-08-15 Published:1994-08-15

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摘要： 来自5位正常成人真皮的成纤维细胞分别用萱草花提取液(EHCB)、表皮生长因子(EGF)、以及EHCB加EGF处理7天.通过计算各组成纤维细胞数来分析成纤维细胞的增生.结果表明:EHCB能抑制成纤维细胞增生(P<0.01),而EGF却能增强成纤维细胞增生(P<0.01).有趣的是,在EHCB加EGF组中成纤维细胞增生远不如EGF组中明显.并就EHCB及EGF对成纤维细胞增生作用的可能药理机制进行了讨论.

关键词: 纤维母细胞, 萱草花, 表皮生长因子

Abstract: Human dermal fibroblasts from 5 normal adult donors were treated with EHCB, EGF, and EHCB combined with EGF for 7 days respectively.The fibroblast proliferation in each group was determined by counting the cell numbers.Our data indicate that EHCB inhibits the fibroblast proliferation(P<0.01), whereas EGF enhances the fibroblast proliferation (P<0.01).Interestingly, in the group of EHCB plus EGF,fibroblast proliferation was far more slow than that in EGF group.The article also discusses the possible pharmacological mechanism of EHCB and EGF on fibroblast proliferation.

Key words: Fibroblasts, Hemerocallis citrina barroni, Epidermal growth factor