中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (1): 25-27.

• 论著 • 上一篇    下一篇

体外经微波和激光处理后的尖锐湿疣皮损中HPVDNA研究

李红霞, 夏明玉, 朱文元   

  1. 南京妇产医院 210004
  • 收稿日期:1994-01-04 修回日期:1994-05-09 出版日期:1995-02-15 发布日期:1995-02-15

Detection of HPV DNA by PCR in Lesions of Condylomate Acuminata Treated with CO2 Laser and Microwave In Vitro

Li Hongxia, Xia Mingyu, Zhu Wenyuan   

  1. Nanjing Women's Hospital, Nanjing 210004
  • Received:1994-01-04 Revised:1994-05-09 Online:1995-02-15 Published:1995-02-15

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摘要： 我们研究了12个尖锐湿疣的新鲜标本.每个标本分成三等分,第一等分不作处理;第二、三等分分别用CO2激光和微波处理.12个未经处理的皮损用聚合酶链反应均检测出HPV DNA(100%).HPV 16和11型各6例.12例皮损经CO2激光处理后10例(83%)发现HPV DNA.微波处理组HPV DNA 6例阳性(50%),经统计学处理、微波处理后皮损中HPV DNA的阳性率比未处理组明显降低,统计学有显著性差异(χ2=4.18,P<0.05),微波对HPV DNA损害比CO2激光更有效.

关键词: 尖锐湿疣, 聚合酶链反应, 乳头状瘤病毒

Abstract: Twelve specimens of genital warts were excised from 12 patients and divided into three parts.One part was untreated,the second and the third part were treated with CO2 laser and microwave respectively.HPV DNA was amplified and detected in 100% of untreated specimens (HPV16 and HPV11 in six patients each),in 83% and 50% of specimens treated with CO2 laser and microwave respectively.There was a significant difference in the detection rates between untreated and microwave treated specimens (χ2=4.18,P<0.05).Microwave damaged HPV DNA more effectively than CO2 laser.

Key words: Condylomata acuminata, Polymerase chain reaction, Papillomaviruses