中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (1): 22-24.

• 论著 • 上一篇    下一篇

水痘-带状疱疹病毒抗体与带状疱疹患者疼痛的关系

郑捷1, 仓尧卿2, 李卫平1, 张嵘3, 许蕾4, 王平4, 何英1, 周建忠1, 叶雯1, 张传钧1   

  1. 1. 上海第二医科大学附属瑞金医院皮肤科 200025;
    2. 卫生部上海生物制品研究所;
    3. 上海市市政工程局职工医院检验科;
    4. 上海市医学检验所
  • 收稿日期:1994-02-03 修回日期:1994-07-18 出版日期:1995-02-15 发布日期:1995-02-15

Study on the Correlation between Anti-Varicella—zoster Virus Antibody Titers and Severity of Pain in Patients with Herpes

Zoster Zheng Jie1, Cang Raoqing2, Li Weiping1   

  1. Department of Dermatology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025
  • Received:1994-02-03 Revised:1994-07-18 Online:1995-02-15 Published:1995-02-15

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摘要： 用酶标SPA法对68例带状疱疹(HZ)和带状疱疹后遗神经痛(PHN)及HZ半年后无PHN的患者的血清中抗水痘-带状疱疹病毒(VZV)抗体进行了检测,并与35例正常人和非HZ患者血清对照.结果显示HZ在发病一周内其抗VZV抗体大都处于低水平,抗体滴度与年龄无关,仅与疼痛程度有关.HZ在发病一周后其抗体滴度明显升高,该滴度与患者年龄、疼痛程度均呈正相关,即年龄越大,抗VZV抗体滴度越高,疼痛程度也越剧烈.无PHN者在发病半年后其抗VZV抗体均降至正常水平,而有PHN的HZ在一年后抗体仍呈高滴度,显示PHN的发生与抗VZV抗体有密切关系.而对照组抗VZV抗体呈阴性或低滴度阳性.

关键词: 带状疱疹, 抗体, 水痘-带状疱疹病毒

Abstract: The anti-varicella-zoster virus (VZV) antibody titers were determined with the method of enzyme linked SPA in sera from 68 patients with herpe,zoster(HZ) and in sera from 35 controls.The results were as follows:In the first week after the onset of HZ,the VZV antibody titers were low in the majority of patients and there was a positive correlation with the severity of patient's pain,but no correlation with patient's age.The titers of VZV antibody were markedly elevated during the 2nd and 3rd week after disease onset,and in this period,there was a positive correlation with patient's age and severity of pain,i.e.higher titers of VZV antibody were usually found in older patients with more severe pain.In patients without postherpetic neuralgia (PHN),the titers of VZV antibody almost returned to normal level in 6 months after HZ episode,but in patients with PHN,the titers of this antibody still remained in high level after 1 to 2 years,which showed that there was a close relation between the PHN and VZV antibody.The VZV antibodies in control group were negative or within normal range.

Key words: Herpes zoster, Antibodies,varicella-zoster virus