中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (6): 364-366.

• 论著 • 上一篇    下一篇

茴香醛抗真菌实验及临床治疗研究

白玫1, 戴文英1, 杨国玲1, 张玉萍2, 董君3   

  1. 1. 大连医科大学附属第一医院皮肤科, 辽宁, 116011;
    2. 大连铁路医院皮肤科, 辽宁, 160111;
    3. 大连市皮肤病防治所, 辽宁, 160111
  • 收稿日期:1994-07-04 修回日期:1994-12-06 出版日期:1995-12-15 发布日期:1995-12-15

Experimental and Clinical Studies on the Action of Anisaldehyde Against Fungi

Bai Mei1, Dai Wenying1, Yang Guoling1   

  1. First Affiliated Hospital, Dalian Medical University, Dalian 116011
  • Received:1994-07-04 Revised:1994-12-06 Online:1995-12-15 Published:1995-12-15

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摘要： 茴香醛有很强的抗真菌活性,而且抗菌谱广,实验用18种46株真菌MIC为0.039～1.25mg/ml,MFC为0.156～5.0mg/ml.3H-TdR掺入法试验显示对白念珠菌核酸代谢有显着抑制作用,且随浓度增高而增强.扫描电镜观察可见对菌细胞有破坏作用.5%茴香醛酊治疗浅部真菌病治愈率达74.26%.

关键词: 茴香醛, 皮肤真菌, 皮肤真菌病

Abstract: This article reports the results of antimycotic action of Anisaldehyde in vitro and treatment of patients with dermatophytosis.Anisaldehyde showed a marked antimycotic action against 18 common pathogenic fungi,the MIC ranged from 0.039~1.25mg/ml and MFC 0.156-5.0mg/ml.By the method of incorporation with 3H-TdR, we observed the inhibitory effects of anisaldehyde on nucleic acid metabolism of Candida albicans,the higher the concentration, the stronger the inhibition was,showing the same effect as ketoconazole.Observation by SEM showed that the shape of C.albicans.was changed and the cell wall was destroyed by anisaldehyde.5% anisaldehyde tincture was applied to the patients.with dermatophytosis,the cure rate was 74.26%.

Key words: Anisaldehyde, Dermatophytes, Dermatomycoses