中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (4): 255-257.

• 论著 • 上一篇    下一篇

多菌型麻风联合化疗和监测的10年观察结果

沈建平1, 李文忠1, 严良斌1, 叶干运1, 骆钧2, 陈文华2, 邵玉生2, 贺挺书2, 莫焕春2, 陶朗2, 吕绍泉2, 顾刚2, 吕丁文2, 皋官蔚3   

  1. 1. 中国医学科学院、中国协和医科大学皮肤病研究所 南京 210042;
    2. 扬州市皮肤病防治所;
    3. 东台市皮肤病防治院
  • 收稿日期:1995-07-14 修回日期:1995-10-16 出版日期:1996-08-15 发布日期:1996-08-15

Results of Multidrug Therapy on Multibacilary Leprosy and Folow up of Ten Years

Shen Jianping1, Li Wenzhong1, Yan Liangbin1   

  1. Institute of Dermatology, Peking Union Medical Colege, Chinese Academy of Medical Sciences, Nanjing 210042
  • Received:1995-07-14 Revised:1995-10-16 Online:1996-08-15 Published:1996-08-15

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摘要： 为了评价联合化疗对多菌型麻风患者的疗效,对其10年的结果进行了分析.457例多菌型患者在联合化疗中细菌指数(BI)下降情况示,联合化疗前BI≥3.0的经治、复发和新发患者,在治疗60个月时,BI累积阴转率分别为86.4%、63.8%和81.6%.642例患者在联合化疗和监测期分别有10.4%和0.7%的患者发生麻风反应.对550例停药患者监测2520人年,发现1例经治患者复发.我们认为多菌型麻风患者完成联合化疗后,对其密切监测,及时发现反应和复发很有必要.

关键词: 麻风, 药物疗法,联合

Abstract: In order to evaluate the therapeutic effects of multidrug therapy (MDT) on multibacillary leprosy patients,the change of bacteriological index in 457 multibacilary leprosy patients on MDT was studied.The results showed that the patients previously treated with dapsone(DDS)alone,patients relapsed after DDS monotherapy and newly diagnosed patients with BI≥3.0 before MDT,60 months after MDT,the acumulative rates of BI negativity were 86.4%,63.8% and 81.6% respectively.There were 67 cases(10.4%) and 4 cases (0.7%) developed leprosy reaction in the period of MDT and folowing up,respectively.Five hundred and fifty cases were folowed up for 1～8 years,a total of 2520 patient-years,and one patient relapsed at the third year after stopping of MDT.The authors consider that it is necesary to folow up the patients after completion of MDT,for the early diagnosis ofreversal reaction and relapse.

Key words: Leprosy, Drug therapy,combination