中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (4): 249-251.

• 论著 • 上一篇    下一篇

丹参和紫草等复合中药制剂对小鼠血管内皮细胞株生物活性的影响

朱瑾波1, 户田宪一2, 今村贞夫2, 林元珠3   

  1. 1. 河北省中医药研究所皮肤科 石家庄 050031;
    2. 日本京都大学医学部皮肤病研究室;
    3. 河北医科大学第四医院皮肤科
  • 收稿日期:1995-08-14 修回日期:1995-12-07 出版日期:1996-08-15 发布日期:1996-08-15

Efects of Futaibao(a Chinese Traditional Herb Preparation) on Biological Activity of Vascular Endothelial CelLines Derived from Mouse Skin

Zhu Jinbo1, Kenichi Toda2, Sadao Imamura2   

  1. Hebei Institute of the Traditional Chinese Medicine, Shijiazhuang 050031
  • Received:1995-08-14 Revised:1995-12-07 Online:1996-08-15 Published:1996-08-15

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摘要： 为了探讨丹参、紫草、三七、雷公藤等中药复合制剂(肤泰宝)治疗银屑病的机理,利用自己建立的小鼠皮肤血管内皮细胞株F-2和F-2C,观察了肤泰宝对血管内皮细胞生物学活性的影响.结果:①肤泰宝可抑制血管内皮细胞游走、增殖并诱导其分化形成管腔;②促进血管内皮细胞合成细胞外基质成分Ⅳ型胶原蛋白、纤维连接蛋白及基膜连接蛋白;③调节整合素表达;④明显提高钙依赖粘连分子活性.提示肤泰宝能通过多种机理调控血管生成过程.

关键词: 中药, 血管内皮细胞

Abstract: In order to study the mechanism of Futaibao (a Chinese traditional herbpreparation composed of Radix Salviae miltiorrhizae,Radix arnebiae euchroma,Radix notoginseng and Tripterygium wilfordi etc.)in the treatment of psoriasis,vascular endothelial cell lines F-2 and F-2C derived from mouse skin were used to observe the efects of Futaibao on the biological activity of endothelial cell lines.The results showed that:①Futaibao inhibited the migration and proliferation of the endothelial cells,and canalization was induced,②promoted the endothelial cells to synthesize extracelular matrix(collagenⅣ,fibronectin,and laminin),③regulated the expression of integrin,④markedly increased the activity of cadherin.The results suggest that Futaibao controls angiogenesis process through a series of mechanisms.

Key words: Vascular endothelial cell, Herbs,Chinese traditional