中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (6): 430-432.

• 论著 • 上一篇    下一篇

某些化妆品致色素作用的实验研究

黄畋1, 仲珣2   

  1. 1. 大连医科大学附属第二医院皮肤科 116023;
    2. 大连市中心医院皮肤科
  • 收稿日期:1995-09-01 修回日期:1995-12-25 出版日期:1996-12-15 发布日期:1996-12-15

Experimental Study on the Melanogenic Efect of Some Cosmetics

Huang Tian1, Zhong Xun2   

  1. Department of Dermatology, 2nd Afiliated Hospital.Dalian Medical University, Liaoning 116023
  • Received:1995-09-01 Revised:1995-12-25 Online:1996-12-15 Published:1996-12-15

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摘要： 用Imokawa等的实验方法,用10种化妆品及8种化妆品化学成分涂于黄棕色豚鼠侧背部皮肤,然后取材,进行HE染色、黑素染色及Dopa氧化酶染色,以探讨化妆品及其化学成分的致色素作用.结果:10种化妆品均显着增加黄棕色豚鼠表皮基底细胞中含黑素的细胞数,而8种化妆品成分中仅胭脂红、对羟基苯甲酸、柠檬黄、松香、羊毛脂等5种引起此种改变.提示此动物模型易于显示化妆品的致色素作用,又可显示化学品致色素作用的差异.并观察到组织有无炎症反应及反应程度与色素沉着不完全平行,提示化妆品及其成分所致的色素沉着并非全是炎症的后果,因此,在化妆品生产中不仅要避免化妆品中所含的致敏物质,还须设法避免致色素的物质.

关键词: 化妆品, 色素沉着, 豚鼠

Abstract: Pigmented cosmetic dermatitis composes amajor sort of undesirable reactions induced by cosmetics,but the melanogenic efect of cosmetics can scarcely be detected with patch tests inhuman.In the present study,10 cosmeticproduc tsmost frequently used by the patients with pigmented cosmetic dermatitis and 8 ingredients contained in the cosmetics were paintedonto separate are as of the dorsal flank of brow nish guinea pigs folowing the method reported by Imokawa et al,then skin specimens were removed,the parafin imbeded sections were stained with H.E.,Schmorl's reaction was used to show melanin,and Bacher,Praver and That cher's dopa-oxidase reaction to study the melanogenic effect of the cosmetics and the ingredients.

Key words: Melanogensis, Cosmetics, Guineapig, brownish