中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (6): 418-420.

• 论著 • 上一篇    下一篇

新疆Kaposi肉瘤12例免疫电镜观察

普雄明1, 石得仁1, 沈大为2   

  1. 1. 新疆维吾尔自治区人民医院皮肤科, 乌鲁木齐 830001;
    2. 新疆医学院第一附属医院, 乌鲁木齐 830001
  • 收稿日期:1996-09-10 出版日期:1996-12-15 发布日期:1996-12-15
  • 基金资助:

    新疆卫生厅青年科研基金

FⅧRAg、FN、TypeⅣ Colagen、HLA-DR and CMV Antigensin Lesions of Kaposi’s Sarcoma:An Immune Electron Microscopic Study

Pu Xiongming1, Shi Deren1, Shen Dawei2   

  1. Dept of Dermatology, XinJiang People's Hospital, Urumiqi 830001
  • Received:1996-09-10 Online:1996-12-15 Published:1996-12-15

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摘要：

用第8因子相关抗原(FⅧRAg)、纤维连接蛋白(FN)、Ⅳ型胶原、HLA-DR抗原和巨细胞病毒抗原(CMV)5种标记抗体,对12例新疆Kaposi肉瘤(KS)瘤组织进行了免疫电镜观察.结果表明,KS组织内FⅧRAg、FN及Ⅳ型胶原均有阳性表达,特别是FⅧRAg主要见于明细胞内,暗细胞极少,FN在明、暗两种瘤细胞及间质中均可见到,Ⅳ型胶原主要见于少数基膜上,这一结果进一步证明KS虽是一血管肿瘤,但可能不是单一的内皮起源,而是起源于血管内皮和周细胞的观点.同时在12例KS组织内均见有CMV和HLA-DR抗原的胶体金颗粒沉积,而作为对照的8例白癜风皮损除在真皮浅层见有少数树突状HLA-DR阳性细胞外,CMV抗原均为阴性,它提示CMV感染可能在KS的发生过程中起着重要作用.

关键词: Kaposi肉瘤, 第8因子相关抗原, 纤维连接蛋白, Ⅳ型胶原, HLA-DR抗原, 巨细胞病毒

Abstract:

The authors have examined the presence and distribution of factor Ⅷ relatedantigen(FⅧRAg),fibronectin (FN),type Ⅳ colagen,HLA-DR and CMV antigens in the lesions of Kaposi's sarcoma by immuneele ctron microscopic method.The resalts showed that FⅧRAg、FN and type Ⅳcolagen were observed in the lesions of Kaposi's sarcoma.In two tumorcels,the FⅧRAg was frequently found in light cells showing cytologic characteristic of endothelial cells but not in the dark cells,probably of pericytic origin.

Key words: Kaposi’s sarcoma, FⅧRAg, FN, TypeⅣ colagen, HLA-DR antigen, CMV