中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (6): 412-414.

• 论著 • 上一篇    下一篇

紫外线辐射的尿刊酸对T淋巴细胞增殖的影响

王韬1, 毕志刚2, 陈华群1, 丁小健1   

  1. 1. 江苏省人民医院临床实验研究室 210029;
    2. 南京医科大学第一附属医院皮肤科
  • 收稿日期:1995-11-02 修回日期:1996-02-01 出版日期:1996-12-15 发布日期:1996-12-15
  • 基金资助:
    国家自然科学基金

Efects of cis-Urocanic Acid Irradiated by UV upon the Tlymphocyte Proliferation

Wang Tao1, Bi Zhigang2, Chen Huaqun1   

  1. The People's Hospital of Jiangsu Province, Nanjing 210029
  • Received:1995-11-02 Revised:1996-02-01 Online:1996-12-15 Published:1996-12-15

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摘要： 为了探讨紫外线激活的顺式尿刊酸对T淋巴细胞的作用和可能的机理,我们采用植物血凝素刺激T淋巴细胞增殖反应的方法研究了顺式尿刊酸、反式尿刊酸、磷酸组胺对T淋巴细胞增殖反应的影响,并进一步观察了组胺H2受体阻断剂甲氰咪胍对顺式尿刊酸和组胺的阻断作用.结果发现,0.2mmol/L顺式尿刊酸和0.2mmol/L磷酸组胺能有效地抑制T淋巴细胞的增殖反应,而0.2mmol/L反式尿刊酸则不能抑制增殖反应.2.0mmol/L甲氰咪胍能阻断顺式尿刊酸和磷酸组胺的抑制作用.结果提示顺式尿刊酸能通过组胺H2受体抑制T淋巴细胞的增殖反应,并且其免疫抑制机理可能类似于组胺.

关键词: 尿刊酸, 受体 组胺H-2, 免疫抑制

Abstract: Tos tudy the possible immunosuppression mechanism of cis-urocanic acid(cis-UCA)ir-radiated by UV,the proliferation test by phytohemagglutinin(PHA) was carried out to investigate whether and how the cis-UCA、trans-UCA and histamine phosphate influence the Tlymphocyte.Also it was disscused if the H2 receptor of Tlymphocyte play an important role in the immunosuppression of cis-UCA and histamine.Th eresults showed that 0.2 mmol/L cis-UCA and 0.2 mmol/L histaminephos-phate significantly inhibited the Tlymphocyte proliferation by PHA,however,0.2 mmol/L trans-UCA did not.2.0 mmol/L cimetidine could block the inhibitory effects of cis-UCA and histamine phosphate.The seresults indicate that cis-UCA can inhibit the Tlymphocyte proliferation by H2 receptor,further-more,immunosuppression mechanism of cis-UCA may be similar to histamine.

Key words: Urocanic acid, Receptors, histamine H2, Immunosuppression