中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (6): 405-407.

• 论著 • 上一篇    下一篇

儿童泛发性脓疱型银屑病23例临床分析

崔盘根, 刘训荃, 朱登平, 李锋   

  1. 中国医学科学院, 中国协和医科大学皮肤病研究所, 南京 210042
  • 收稿日期:1996-02-17 修回日期:1996-06-18 出版日期:1996-12-15 发布日期:1996-12-15

An Analysis of 23 Inpatients with Generalized Pustular Psoriasis in Children

Cui Pangen, Liu Xun-quan, Chen Kun   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical Colege, Nanjing 210042
  • Received:1996-02-17 Revised:1996-06-18 Online:1996-12-15 Published:1996-12-15

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摘要： 儿童泛发性脓疱型银屑病(GPP)临床上较为少见.现分析了23例住院儿童GPP,男16例,女7例;年龄2～12岁,平均7.35岁.临床观察表明,上呼吸道感染及不规则使用皮质类固醇激素治疗,是GPP诱发和加重的重要因素.雷公藤、氨苯砜、红霉素联合应用对GPP具有协同疗效,治疗20例患儿,1～2周内治愈率达35%,总有效率为80%,可作为首选治疗方案;Tigason、甲氨喋呤作为二线药物选用;皮质类固醇激素不推荐为常规治疗药物.患儿年龄、原发病及治疗选择对预后具有一定影响.

关键词: 脓疱型银屑病, 治疗学

Abstract: Generalized pustular psoriasis(GPP) in children is rare.Twenty-three inpatients with GPP in children(16 males and 7 females,age ranged from 2 to 12 years,with an average of 7.35 years)were analyzed.Clinical observation revealed that upper respiratory tract infection and irregular corticosteroid therapy were important factors in inducing and aggravating the disease.Twenty patients were treated with a combination of Leigongteng(Tripterygium wilfordi),dapsone and erythromycin,7 of them(35%)cured,9(45%)improved in 1～2 weeks.It is th eauthor's opinion that the above regimen is the first choice of treatment for GPP,and tigason、methotrexate are the alternatives,while corticosteroids are not recommended as the routine therapeutic drugs.The children's age,underlying disease and the rapeutic regimen have efect on prognosis of the disease.

Key words: Pustular psoriasis, Therapeutics