中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (4): 251-252.

• 论著 • 上一篇    下一篇

过敏性接触性皮炎反应中浸润T细胞类型研究

白亚来1, 张春雷1, 曾灵芳2, 谢志强1, 李世荫1   

  1. 1. 北京医科大学第三医院皮肤科 100083;
    2. 北京医科大学病理系
  • 收稿日期:1996-09-03 修回日期:1996-12-30 出版日期:1997-08-15 发布日期:1997-08-15

Study of the Type of Infiltrating T Cells in Allergic Contact Dermatitis

Bai Yalai1, Zhang Chunlei1, Zeng Lingfang2   

  1. Department of Dermatology, The 3rd Hospital of Beijing Medical University, Beijing 100083
  • Received:1996-09-03 Revised:1996-12-30 Online:1997-08-15 Published:1997-08-15

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摘要： 为了观察过敏性接触性皮炎(ACD)反应浸润T细胞的类型,本实验用逆转录聚合酶链反应(RT-PCR)及免疫组化方法对18例ACD急性期患者皮损进行了白介素2mRNA及白介素2、γ干扰素、白介素4表达的研究。结果:与对照组织相比,绝大多数ACD标本有Th1型细胞因子的表达,且定位于真、表皮浸润的淋巴细胞胞浆中。结果提示ACD反应是以Th1型细胞增殖为主的反应。

关键词: 皮炎, 接触性, 白介素2, 干扰素γ

Abstract: In order to investigate the type of infiltrating T cells in allergic contact dermatitis (ACD) reaction, by the methods of RT-PCR and immunohistochemistry, we tried to detect IL-2mRNA, IL-2, IFN-γ, IL-4 in the lesions of patients with ACD. The results showed that Th1 cytokines were expressed aberrantly in ACD patients and Th1-like clone which secrets IL-2, IFN-γ appeared to be predominant in ACD reaction.

Key words: Dermatitis, contact, Interleukin-2, Interferon γ