中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (1): 9-11.

• 论著 • 上一篇    下一篇

系统性红斑狼疮患者自身抗体与HLA-DR、DQ基因的相关性研究

彭学标1, 徐文严1, 费虹明2, 岳晓玉1, 陈仁彪2   

  1. 1. 中国医学科学院、中国协和医科大学皮肤病研究所, 南京210042;
    2. 上海第二医科大学生物学教研室
  • 收稿日期:1997-01-16 修回日期:1997-05-24 出版日期:1998-02-15 发布日期:1998-02-15

Study on the Association Between HLA-DR, DQ Genes and Autoantibodies in Pateints with Systemic Lupus Erythematosus

Peng Xuebiao1, Xu Wenyan1, Fei Hongming2   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042
  • Received:1997-01-16 Revised:1997-05-24 Online:1998-02-15 Published:1998-02-15

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摘要： 目的 探讨系统性红斑狼疮 (SLE)的发病机理和遗传基础。方法 分析了SLE患者中各种自身抗体与HLA-DR、DQ基因的关联。结果 发现抗Ro抗体与DR2、DQ6及DQ2/DQ6杂合子相关,抗RNP抗体与DQA 1*0102、DQB1*0602相关。抗Sm和抗dsDNA抗体均与DRB1*1501、DQ A1*0102、DQB1*0602相关,这与汉族SLE与HLA的关联完全一致,表明抗Sm和抗dsDNA抗体对SLE有极高的诊断价值。结论 自身抗体与HLA的关联跨越了种族界限,不同种族的SLE患者中同种自身抗体与HLA抗原的关联基本相同,提示 HLA对SLE的遗传易感作用主要发生在自身抗体水平。

关键词: 红斑狼疮,系统性, 自身抗体

Abstract: Objective To study the pathogenesis and genetic basis of systemic lupus erythematosus (SLE).Methods The association between HLA-DR,DQ genes and various autoantibodies in patients with SLE was analysed. Results The results indicated that DR2,DQ6 and the heterozygous combination DQ2/DQ6 were closely correlated with the production of autoantibodies to Ro antigen,and DQ A1*0102, DQB1*0602 with antibody to RNP. As shown in the lupus population study in H an nationality,patients with anti-Smand anti-dsDNA antibodies were associated with DRB1*1501,DQA1*0102,and DQB1*0602 which suggests that anti-Smand anti-dsDNA antibodies have a very im portant diagnostic value in SLE.Conclusion The association between autoantibodies and HLA has gone beyond ethnic boundary.In various ethnic patients with SLE,the associaton between HLA antigen and specific autoantibody is similar.The above data suggest that contribution of class MHC molecules in SLE is predominantly at the level of specific autoantibodies production.

Key words: Lupus erythematosus, systemic, Autoantibodies