中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (4): 244-246.

• 论著 • 上一篇    下一篇

四种中药复方对小鼠实验性皮炎作用的研究

涂彩霞1, 林熙然1, 谷玲2   

  1. 1. 大连医科大学附属第一医院皮肤科 辽宁 116011;
    2. 大连医科大学附属第一医院核医学科
  • 收稿日期:1997-08-01 修回日期:1998-01-23 出版日期:1998-08-15 发布日期:1998-08-15
  • 基金资助:
    辽宁省教委资助课题

The Effects of 4 Traditional Chinese Medicinal Compounds on Murine DNFB Dermatitis

Tu Caixia1, Lin Xiran1, Gu Lin2   

  1. First Affiliated Hospital of Dalian Medical University 116011
  • Received:1997-08-01 Revised:1998-01-23 Online:1998-08-15 Published:1998-08-15

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摘要： 目的 为了探讨中医治则和方剂组成与治疗湿疹有关的实验药效学作用之间的关系.方法 利用小鼠二硝基氟苯变应性接触性皮炎动物模型,以具有抑制Ⅳ型变态反应的中药,组成4个不同的复方,进行动物实验.结果 兼有凉血活血、清热祛风、利湿多种功效的Ⅲ方(赤芍、栀子、荆芥、浮萍、茯苓)作用最好,并显示诱发皮炎后小鼠血浆降钙素基因相关肽降低,投与中药可对此具有上调的作用.结论 按中医理法选用具有抑制Ⅳ型变态反应的中药组方可在临床中进行验证.

关键词: 皮炎,变应性接触性, 中药

Abstract: Objective To study the relationship between the therapeutic principle and prescription of traditional Chinese medicine and the experimental pharmacologic effects in relation to the treatment of eczema. Methods Murine DNFB allergic contact dermatitis was used as an animal model, and was treated with 4 traditional Chinese medicinal compounds which were composed of Chinese materia medica with activities to suppress type Ⅳ allergic reaction. Results The results showed that the effect of compound Ⅲ composed of Paeoniae obovata Maxim(赤芍), Fructus Gardeniae(栀子), Herba Schizonepetae(荆芥), Herba Spirodelae(浮萍) and Poria(茯苓), possessing multiple potencies of cooling and promoting blood, clearing heat, expelling wind and eliminating dampness, was strongest among the compounds tested, and the compound up regulated the serum level of calcitonin gene related peptide which was lowered in the mice with DNFB induced dermatitis. Conclusion It is suggested that the compounds with suppressive effect on type Ⅳ allergic reaction might improve the therapeutic effect in clinical practice.

Key words: Dermatitis,allergic contact, Medicine,traditional Chinese