中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (4): 239-240.

• 论著 • 上一篇    下一篇

尖锐湿疣患者肿瘤坏死因子α、白介素6和白介素8水平的研究

王岚, 陈映玲, 周礼义   

  1. 同济医科大学附属同济医院皮肤科 武汉 430030
  • 收稿日期:1997-03-17 修回日期:1998-01-05 出版日期:1998-08-15 发布日期:1998-08-15

Study of the Levels of TNF-,IL-6,IL-8 in Patients with Condyloma Acuminatum

Wang Lan, Chen Yingling, Zhou Liyi   

  1. Department of Dermatology, Tongji Hospital, Tongji Medical University, Wuhan 430030
  • Received:1997-03-17 Revised:1998-01-05 Online:1998-08-15 Published:1998-08-15

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摘要： 目的 研究肿瘤坏死因子(TNF-)、白介素6(IL-6)和白介素8(IL-8)在尖锐湿疣发病机理中的作用.方法 采用ELISA双抗体夹心法,测定了21例尖锐湿疣患者血浆、内毒素刺激的外周血单一核细胞培养上清液和17例患者疣体组织TNF-、IL-6、IL-8含量.结果 尖锐湿疣患者组的血浆刺激的外周血单一核细胞分泌的TNF-、IL-6、IL-8水平显着低于正常人组;疣体组织的IL-6、IL-8水平显着低于正常人组;两组组织中TNF-均未能检出.结论 尖锐湿疣患者全身和皮损局部存在着单核-巨噬细胞功能下降,而这种功能下降可能是导致尖锐湿疣患者淋巴细胞功能缺陷的重要原因.提高单核-巨噬细胞功能,对尖锐湿疣的防治,可能具有一定意义.

关键词: 尖锐湿疣, 肿瘤坏死因子, 白介素6, 白介素8

Abstract: Objective To study the role of tumor necrosis factor alpha(TNF-), interleukin(IL) 6 and IL-8 in the pathogenesis of condyloma acuminatum(CA). Methods Double-antibody sandwich ELISA was used to study the levels of TNF-,IL-6 and IL-8 in 21 cases of CA. Results The results showed that the levels of TNF-,IL-6 and IL-8 of the plasma in the patients were significantly lower than those of normal controls. The levels of TNF-,IL-6 and IL-8 produced by peripheral blood mononuclear cells in response to LPS mitogen in vitro significantly decreased in comparison with those of normal controls. The levels of IL-6 and IL-8 of the wart tissues excised from 17 patients were significantly lower than those of normal tissue. No TNF- was detected in the tissues of both patient and normal groups. Conclusion These findings suggest that the monocyte macrophage function of CA patients might be decreased systemically and locally which may contribute to the disorder of lymphocyte function. Improvement of the monocyte macrocyte function might have some significant effect on the prevention and treatment of CA.

Key words: Condyloma acuminatum, Tumor necrosis factor-, Interleukin 6, Interleukin 8