中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (4): 224-226.

• 论著 • 上一篇    下一篇

172株解脲支原体的血清学分型研究

王荷英, 施美琴, 叶顺章, 王红春, 孙厚华, 戴秀琴   

  1. 中国医学科学院、中国协和医科大学皮肤病研究所 南京 210042
  • 收稿日期:1997-11-21 修回日期:1998-02-25 出版日期:1998-08-15 发布日期:1998-08-15
  • 基金资助:
    中国医学科学院、中国协和医科大学科研基金资助课题

Study on Serotypes of 172 Strains of Ureaplasma urealyticum

Wang Heying, Shi Meiqin, Ye Shunzhang   

  1. Institute of Dermatology,Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042
  • Received:1997-11-21 Revised:1998-02-25 Online:1998-08-15 Published:1998-08-15

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摘要： 目的 为了探讨解脲支原体(Uu)不同血清型与致病性关系.方法 对来自STD门诊的172株Uu作了1～14型血清学分型.Uu株经纯化后,应用代谢抑制试验判定.结果 可分型Uu株达到100%,属单一型有150株(872%),混合型占22株(128%).出现频率高的血清型依次为:4型31株(154%),1型31株(154%),3型24株(119%),8型20株(10%),14型18株(9%),6型16株(8%),其他血清型较少(占3%～65%),未见7型Uu株.结果显示,血清型与性别无关(P>005),但非淋菌性尿道炎患者3型Uu株女性多于男性(P<005).172株中102株Uu系由非淋菌性尿道炎患者的标本中分离出,单一型占90株(882%),混合型占12株(118%).出现频率高的血清型为4、1和8型,各占10%以上.其中以4型为最高,占25株(216%).结论 4型与非淋菌性尿道炎发生呈显着相关.作者认为,Uu株3型在宿主因素和一定的环境条件下,寄居和致病状态可相互转化.

关键词: 尿素支原体,尿素分解, 血清分型

Abstract: Objective To study the relationship between different serotypes of Ureaplasma urealyticum and their pathogenesis. Methods 172 strains of Ureaplasma urealyticum were isolated from specimens of STD clinic patients, and pure cultures were serotyped by metabolic inhibition test. Results The results showed that all of the strains could be typed, in which, 150 strains (87 2%) attributed to a single type and 22 strains (12.8%) mixed serotypes. Serotypes frequently found were as follows: serotype 4 and 1 (both 31 strains,15.4%), serotype 3 (24 strains,11.9%), serotype 8 (20 strains,10%), serotype 14 (18 strains,9%), serotype 6 (16 strains,8%). Other serotypes were uncommen (3%～6.5%), serotype 7 was not found. No association was found between serotype and sex (P>0.05), except serotype 3 from NGU patients, which was more commonly found in women than in men (P<0.05). Of 172 strains, 102 were isolated from NGU patients. Ninety strains (88.2%) were attributed to a single serotype, and 12 strains (11.8%) mixed serotypes. Serotypes 4,1,and 8 were found frequently (>10%, respectively). Conclusion Serotype 4 was the one most frequently found and strongly related with NGU. It is suggested that the transformation from colonization to pathogenetic status be possible for serotype 3 under the influence of host and a certain environmental condition.

Key words: Ureaplasma urealyticum, Serotyping