中华皮肤科杂志 ›› 1999, Vol. 32 ›› Issue (4): 232-233.

• 论著 • 上一篇    下一篇

系统性红斑狼疮患者外周血单一核细胞CD40L表达增加及其临床意义

邓安梅1, 仲人前1, 陈孙孝2, 施笑梅1, 孔宪涛1   

  1. 1. 上海第二军医大学附属长征医院全军临床免疫中心 200003;
    2. 上海第二军医大学附属长征医院皮肤科
  • 收稿日期:1998-08-26 修回日期:1999-01-04 出版日期:1999-08-15 发布日期:1999-08-15
  • 基金资助:
    国家自然科学基金39770702

Increased Expression of CD40L on PBMC in Patients with Systemic Lupus Erythematosus

DENG Anmei1, ZHONG Renqian1, CHEN Sunxiao2   

  1. Clinical Immunology Center, Changzheng Hospital, Shanghai 200003
  • Received:1998-08-26 Revised:1999-01-04 Online:1999-08-15 Published:1999-08-15

PDF

249

赞

摘要： 目的 了解CD40L在SLE患者自身抗体及免疫复合物形成中的作用.方法 采用流式细胞计数仪,对10例活动期SLE、10例缓解期SLE患者外周血单一核细胞CD40L的表达进行了研究.结果 活动期SLE组CD40L表达在抗CD3单抗刺激前后均显着高于正常对照组,而缓解期SLE组T细胞在抗CD3单抗刺激前的CD40L表达在正常范围内,在刺激后显着高于正常对照组.结论 SLE中CD40-CD40L途径存在缺陷,为进一步探讨SLE的发病机制提供了线索.

关键词: 红斑狼疮,系统性, CD40L

Abstract: Objective To investigate the role of CD40L in the production of autoantibody and immune complex-mediated tissue damage. Methods The expression of CD40L on PBMC in patients with active or remission SLE was examined by flowcytometry. Results The CD40L expression in pateints with active SLE increased significantly before and after the stimulation of anti-CD3 mAb in comparison with normal controls. However, the CD40L expression in patients with remission SLE was normal before the stimulation and increased significantly after the stimulation of anti CD3 mAb. Conclusion There is a defect of the CD40-CD40L pathway in SLE.

Key words: Lupus erythematosus, systemic, CD40L