中华皮肤科杂志 ›› 2000, Vol. 33 ›› Issue (4): 261-263.

• 论著 • 上一篇    下一篇

系统性红斑狼疮患者血清生长激素和泌乳素动态变化的研究

李峰1, 冯树芳1, 徐金华1, 黄岚1, 邓守贞2   

  1. 1. 上海医科大学华山医院皮肤科 200040;
    2. 上海医科大学华山医院核医学科
  • 收稿日期:1999-09-27 出版日期:2000-08-15 发布日期:2000-08-15
  • 基金资助:
    国家自然科学基金资助项目(39770688)

Study on Dynamic Changes of Serum Growth Hormone and Prolactin in Patients with Systemic Lupus Erythematosus

LI Feng1, FENG Shufang1, XU Jinhua1   

  1. Affiliated Huashan Hospital, Shanghai Medical University, Shanghai 200040
  • Received:1999-09-27 Online:2000-08-15 Published:2000-08-15

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摘要： 目的 探讨SLE患者生长激素和泌乳素对促甲状腺激素释放激素反应。方法 用双抗体RIA法测定促甲状腺激素释放激素注射前及注射后15、30、60、120minSLE患者和正常人对照组的血清生长激素和泌乳素。结果 SLE活动期患者注射前和注射后15、30、60、120min血清泌乳素水平以及在60、120min时血清生长激素水平显著高于SLE静止期及正常人对照组(P<0.01);SLE静止期与正常人对照组生长激素和泌乳素水平于各时点差异均无显著性(P>0.05);SLE活动期促甲状腺激素释放激素兴奋试验反应升高的发生率显著高于静止期(P<0.01);促甲状腺激素释放激素反应升高与SLE患者病情活动性相关。结论 高生长激素和泌乳素血症与SLE的发生有一定关系。

关键词: 红斑狼疮,系统性, 普罗瑞林, 生长激素(人), 泌乳素

Abstract: Objective To study the response of growth hormone(GH) and prolactin(PRL) to thyrotropin-releasing hormone(TRH) in patients with systemic lupus erythematosus (SLE). Methods The levels of PRL and GH level were measured by radioimmunoassay in sera from 34 patients with active SLE,13 patients of inactive SLE and 10 matched controls. Results There was a significant difference of serum levels of PRL between active group and inactive group as well as controls at 0 min and at 15 min,30 min, 60 min,120 min after TRH injection. The serum GH levels at 60 min and 120 min were significantly higher in active group than those of inactive group and controls. The proportions of patients with increased response to TRH were signifiat higher in active group than those of inactive group. The abnormal response to TRH in active SLE was related to the disease activity of the patients. Conclusion The increasing levels of serum GH and PRL is likely to be associated with the pathogenesis of SLE.

Key words: Lupus erythematosus,systemic, Protirelin, Somatropin, Prolactin