中华皮肤科杂志 ›› 2001, Vol. 30 ›› Issue (1): 34-35.

• 论著 • 上一篇    下一篇

川芎素对系统性硬皮病患者循环内皮细胞的影响

李尚珠, 刘春华, 黄平平, 付仁敏, 吴立华, 王书桂, 钱冠清   

  1. 中国医学科学院、中国协和医科大学血液学研究所血液病医院, 天津 300020
  • 收稿日期:2000-05-08 出版日期:2001-02-15 发布日期:2001-02-15

Effect of Sodium Feralate on the Circulating Endothelial Cells From Patients With Progressive Systemic Sclerosis

LI Shangzhu, LIU Chunhua, HUANG Pingping   

  1. Hospital of Blood Diseases. Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300020
  • Received:2000-05-08 Online:2001-02-15 Published:2001-02-15

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摘要： 目的 观察系统性硬皮病(PSS)患者循环内皮细胞(CEC)数量的变化,了解PSS患者的血管内皮细胞受损伤情况及川芎素对PSS患者血管内皮细胞的影响,探讨川芎素治疗PSS的疗效机理.方法 使用川芎素治疗PSS患者38例,观察治疗前后CEC的数量变化,以53例健康人的CEC数量作为对照比较.结果 经川芎素治疗后,38例PSS患者的皮肤硬化、末梢疼痛、冷感、溃疡指数均有明显的改善(P<0.01).治疗前PSS患者的CEC数量(3.40±1.27个/0.9μL)明显高于健康对照组(1.13±0.48个/0.9μL),治疗后随着临床症状、体征的好转,CEC数量也显著下降(1.80±0.58个/0.9μL).结论 川芎素治疗PSS不仅能显著改善临床症状和体征,而且对PSS患者的血管内皮细胞损伤也有较好的治疗和保护作用.

关键词: 硬皮病,系统性, 内皮,血管, 川芎素

Abstract: Objective To observe the quantity of circulating endothelial cells (CECs)in patients with progressive systemic sclerosis (PSS),and to investigate the effect of sodium ferulate (SF)on the vascular endothelial cell (VEC)of PSS patients. Methods 38 PSS patients were treated with SF,CEC of all patients were detected quantitatively before and after the treatment,and compared with that of 53 healthy controls. Results After the treatment with SF,the skin sclerosis,distal pain,cold sensation,and ulcer index in 38 PSS patients were improved (P<0.01);the number of CEC also decreased,from 3.40± 0.27/0.9μL before treatment which was markedly higher than that of normal controls (1.13± 0.48/0.9μL)to 1.80± 0.58/0.9μL after treatment. Conclusion SF can not only improve the clinical manifestations of the PSS patients,but protects the VECs from injury and has a good therapeutic effect on PSS patient.

Key words: Scleroderma,systemic, Endothelium,vascular, Sodium ferulate