中华皮肤科杂志 ›› 2001, Vol. 30 ›› Issue (1): 25-27.

• 论著 • 上一篇    下一篇

系统性红斑狼疮患者bcl-2及Fas、Fas配体表达与淋巴细胞凋亡的关系

郭在培, 熊琳, 蒋献, 周光平   

  1. 华西医科大学第一医院皮肤性病科, 成都 610041
  • 收稿日期:1999-12-27 出版日期:2001-02-15 发布日期:2001-02-15
  • 基金资助:
    川医学奖学金同学会科研基金资助

Relationship Between the Expression of bcl-2,Fas/FasL and the Apoptosis of Peripheral Lymphocytes in Patients with Systemic Lupus Erythematosus

GUO Zaipei, XIONG Lin, JIANG Xian   

  1. Department of Dermatovenereology, First Hospital, West China University of Medical Sciences, Chengdu 610041
  • Received:1999-12-27 Online:2001-02-15 Published:2001-02-15

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摘要： 目的 对SLE患者外周血淋巴细胞凋亡率以及凋亡调控基因表达蛋白bcl-2、Fas抗原和Fas配体进行分析,以进一步探讨其在SLE发病中的作用及相互关系.方法 应用流式细胞仪检测.结果 SLE患者外周血淋巴细胞凋亡率明显高于正常人(P<0.01)和其他疾病患者(P<0.05);bcl-2抗原表达显著低于正常人和其他疾病患者(P<0.01),而Fas抗原、Fas配体表达三组间无明显差异.结论 SLE患者体内淋巴细胞凋亡的明显增加可能与其发病有关,而bcl-2对淋巴细胞凋亡抑制作用的减弱可能较Fas/Fas配体诱导促进淋巴细胞的凋亡更为重要.

关键词: 红斑狼疮,系统性, 淋巴细胞, 脱噬作用, 基因,bcl-2, Fas抗原, Fas配体

Abstract: Objective To study the relationship between bcl-2,Fas and Fas ligand (FasL) and the role of them in the pathogenesis of systemic lupus erythematosus (SLE). Method Flow cytometry was used. Results Apoptosis of peripheral lymphocytes was significantly increased in SLE patients than that of normal controls(P<0.01)and patients with other skin diseases(P<0.05); the expression of bcl-2 antigen was significantly decreased compared with those of normal controls and patients with other skin diseases(P<0.01); whereas the differences of Fas and FasL expression among the three groups were not significant. Conclusions Increased apoptosis of peripheral lymphocytes may be related to the pathogenesis of SLE,and decreased bcl-2 antigen rather than Fas/FasL route may be more important for the increased apoptosis of peripheral lymphocytes.

Key words: Lupus erythematosus,systemic, Lymphocytes, Apoptosis, Genes,bcl-2, Antigens,Fas, Ligand,Fas