中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (6): 439-441.

• 论著 • 上一篇    下一篇

桥粒芯糖蛋白1和2在不同表皮肿瘤中的表达

韩钢文, 汤占利, 涂平, 赵俊郁, 武玲慎, 朱学骏   

  1. 北京大学第一医院皮肤科 100034
  • 收稿日期:2001-11-15 出版日期:2002-12-15 发布日期:2002-12-15
  • 基金资助:
    2000年度中华医学会皮肤科学杨森科研基金资助

Expression of Desmoglein 1 and 2 in Different Epidermal Tumors

HAN Gangwen, TA NG Zhanli, TU Ping, ZHAO Junyu, WU Lingshen, ZHU Xuejun   

  1. Department of Dermatology, First Hospital of Peking University, Beijing 100034, China
  • Received:2001-11-15 Online:2002-12-15 Published:2002-12-15

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摘要： 目的 探讨桥粒相关蛋白与皮肤肿瘤的关系,对桥粒芯糖蛋白1和2在鳞状细胞癌、日光性角化病、角化棘皮瘤、脂溢性角化病中的表达水平进行了比较研究.方法 免疫组化染色方法.结果 桥粒芯糖蛋白1和2在正常皮肤表皮全层细胞间呈现较强的染色,鳞状细胞癌组织中表达显着减弱或完全无表达,日光性角化病表皮正常区域表达正常或下调,细胞间变区域无染色,角化棘皮瘤和脂溢性角化病表皮中表达水平与正常皮肤的表达非常近似.结论 桥粒芯糖蛋白1和2在恶性皮肤癌中表达下调,可能与皮肤肿瘤的侵袭和转移有关.

关键词: 癌,鳞状细胞, 角化病, 角化棘皮瘤, 角化病,脂溢性, 桥粒芯糖蛋白

Abstract: Objective To evaluate the relationship between desmosome-related proteins and epidermal tumors. Methods Using anti-desmoglein 1 and 2 monoclonal antibodies, expression of desmoglein 1 and 2 was examined by an immunohistochemical staining method in various epidermal tumors such as squamous cell carcinoma (SCC), actinic keratosis(AK), keratoacanthoma(KA) and seborrhoeic keratosis(SK). Results Desmoglein 1 and 2 were strongly expressed in intercellular space of whole epidermis in normal human skin. Expression of desmoglein 1 and 2 was markedly reduced or absentin SCC cells. Compared with normal epidermal cells, expressi on of desmoglein 1 and 2 was equal to or reduced,with complete absence of staining in dysplastic areas in AK cells. Extensive pericellur staining of desmoglein 1 and 2 was found in KA and SK cells, similar to that observed in normal epidermis. Conclusion Expression of desmoglein 1 and 2 is markedly reduced or absent i n human malignant epidermal cancers, reduction of these molecules may contribute to invasiveness and metastasis of epidermal carcinomas.

Key words: Carcinoma, squamous cell, Keratosis, Keratoacanthoma, Keratosis, seborrhoeic, Desmoglein