中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (6): 423-424.

• 论著 •    下一篇

表皮肿瘤细胞中β-连环蛋白的分布

陈翔, 谢红付, 杜乾君, 陈明亮, 陈服文   

  1. 中南大学湘雅医院皮肤科 长沙 410008
  • 收稿日期:2001-12-10 出版日期:2002-12-15 发布日期:2002-12-15

Cellular Distribution of a-catenin in Epidermal Tumors

CHEN Xiang, XIE Hongfu, DU Qianjun, CHEN Mingliang, CHEN Fuwen   

  1. Department of Dermatology, XiangYa Hospital, Central South University, Changsha 410008, China
  • Received:2001-12-10 Online:2002-12-15 Published:2002-12-15

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摘要：

目的 探讨β-连环蛋白在表皮肿瘤中的亚细胞分布及其意义.方法 选择Bowen病(BD)、鳞状细胞癌(SCC)和基底细胞癌(BCC)患者各20例,运用免疫组化方法观察肿瘤细胞中β-连环蛋白的表达.结果 与正常表皮相比,β-连环蛋白在BCC和SCC肿瘤细胞膜上的表达显着降低,而在SCC和BD肿瘤细胞的胞浆或胞核中的表达显着升高.结论 SCC和BD肿瘤细胞的胞浆或胞核区的β-连环蛋白的聚集可能源于β-连环蛋白基因突变,并可能在表皮肿瘤发生中发挥重要作用.

关键词: 癌,鳞状细胞, 癌,基底细胞, Bowen病, β-连环蛋白

Abstract:

Objective To examine the cellular distribution and the role of β-catenin in epidermal tumors. Methods Expression of a-catenin was investigated by immunohistochemical staining in 20 patients with Bowen's disease (BD), 20 squamous cell carcinoma (SCC), 20 basal cell carcinoma (BCC), and 40 normal cont rols. Results Expression of β-catenin was strongest on the cell membranes of basal cells, but nearly negative in the cytoplasm and the nuclei of epidermal cells in normal controls. Expression of β-catenin was significantly lower on the cell membranes in SCC and BCC cells than that in normal epidermal cells (P<0.001). Significantly stronger expression of β-catenin was found in the cytoplasm and nuclei of BD and SCC cells than that of normal controls (P<0.001 and P=0.005, respectively). Conclusion The accumulation of β-catenin in the cytoplasm and nuclei of BD and SCC cells might bedue to mutation of β-catenin gene. The increased β-catenin may have an important role in the development of epidermal tumors.

Key words: Carcinoma, squamous cell, Carcinoma, basal cell, Bowen’s disease, β-catenin