中华皮肤科杂志 ›› 2003, Vol. 36 ›› Issue (5): 261-263.

• 论著 • 上一篇    下一篇

淋球菌耐药性与耐药质粒的相关性研究

叶萍1, 李国明2, 吴志华1   

  1. 1. 广东医学院附属医院皮肤科;
    2. 广东医学院微生物学教研室
  • 收稿日期:2002-07-15 出版日期:2003-05-15 发布日期:2003-05-15

Relationship Between Resistant Plasmids and Drug-resistance in Neisseria gonorrhoeae

YE Ping1, LI Guo-ming2, WU Zhi-hua1   

  1. Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China
  • Received:2002-07-15 Online:2003-05-15 Published:2003-05-15

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摘要： 目的 探讨质粒在介导淋球菌耐药中的作用。方法 通过耐药质粒的接合、转化及消除试验,比较试验前后各菌株药物敏感性的改变。结果 耐药性淋球菌菌株通过耐药质粒的接合和转化,可将其耐药性传递给敏感的淋球菌菌株,而耐药质粒的消除可使耐药性淋球菌恢复对某些药物的敏感性。结论 质粒的介导在淋球菌耐药性的形成中起着重要作用。

关键词: 奈瑟球菌,淋病, 质粒, 药物耐受性

Abstract: Objective To explore the role of plasmids in inducing drug-resistance in Neisseria gonorrhoeae.Methods The change of drug-susceptibility in Neisseria gonorrhoeae was compared before and after experiments of resistant plasmids conjugation,transformation and deleting.Results The drug-resistance was transferred from resistant strains to sensitive strains through the conjugation and transformation of resistant plasmids,while the drug susceptibility could be recovered through deleting such plasmids from resistant strains.Conclusion The plasmids play an important role in the development of drug-resistance in Neisseria gonorrhoeae.

Key words: Neisseria gonorrhoeae, Plasmids, Drug resistance