中华皮肤科杂志 ›› 2004, Vol. 37 ›› Issue (2): 100-102.

• 论著 • 上一篇    下一篇

特比萘芬合用地巴唑治疗甲真菌病的随机双盲对照研究

赵学良, 赵克宁, 董秀云, 王振华, 于芳, 王海峰   

  1. 1. 山东潍坊市人民医院皮肤科 261041;
    2. 潍坊医学院皮肤科教研室 261041
  • 收稿日期:2003-03-17 出版日期:2004-02-15 发布日期:2004-02-15
  • 基金资助:
    2001年度中华医学会皮肤科分会科研基金资助

A Randomized, Double Blinded Clinical Trial of Combination of Terbinafine and Dibazol for the Treatment of Onychomycosis

ZHAO Xue-liang, ZHAO Ke-ning, DONG Xiu-yun, WANG Zhen-hua, YU Fang, WANG Hai-feng   

  1. Department of Dermatology, Weifang City People's Hospital, Shandong 261041, China
  • Received:2003-03-17 Online:2004-02-15 Published:2004-02-15

PDF (PC)

86

赞

摘要： 目的 观察特比萘芬与地巴唑联合治疗甲真菌病的疗效。方法 甲真菌病患者随机分组,治疗组口服特比萘芬250mg每日1次,同时口服地巴唑10mg每日3次;对照组口服特比萘芬250mg每日1次,同时口服安慰剂。治疗组指甲真菌病疗程为6周,趾甲疗程为8周;对照组指甲真菌病疗程为8周,趾甲疗程为10周。观察2种方法的疗效。结果 治疗后第24周随访,治疗组54例痊愈率为70.4%(38/54例),有效率为83.3%(45/54例);对照组51例痊愈率为66.7%(34/51例),有效率为80.4%(41/51例),两组比较差异均无显著性(P>0.05)。结论 特比萘芬与血管扩张剂联合治疗甲真80.4%(41/51例),两组比较差异均无显著菌病能缩短疗程,且无明显不良反应。

关键词: 甲癣, 抗生素类,抗真菌, 血管舒张药

Abstract: Objective To observe the effects of the treatment of onychomycosis with the combination of terbinafine and dibazol. Methods The patients were divided into groups randomly. The test group orally took terbinafine 0.25g once daily in combination with dibazol 10mg thrice daily. The control group orally took terbinafine 0.25g once daily and placebo. The treatment course was 6 weeks for those with fingernail onychomycosis, and 8 weeks for those with toenail disease in test group; while 8 weeks for fingernail disease, and 10 weeks for toenail disease in control group. The therapeutic effects of two groups were evaluated. Results There were 54 cases in test group and 51 cases in control group, respectively. At the 24 week after treatment, the clinical cure rate was 70.4% (38/54), and response rate 83.3% (45/54) in test group, while the clinical cure rate 66.7% (34/51), and response rate 80.3% (41/51) in control group. There was no significant difference of clinical cure rates (P>0.05) and response rates (P>0.05) between two groups. Conclusion The results show that the combination of terbinafine and dibazol can improve clinical and mycologic effects and shorten therapeutic course for the treatment of onychomycosis.

Key words: Onychomycosis, Antibiotics, antifungal, Vasodilator agents