中华皮肤科杂志 ›› 2004, Vol. 37 ›› Issue (8): 463-465.

• 论著 • 上一篇    下一篇

球形马拉色菌是马拉色菌毛囊炎患者皮损毛囊内的主要菌种

熊心猜, 冉玉平, 代亚林, 熊琳, 周光平   

  1. 四川大学华西医院皮肤性病科 成都 610041
  • 收稿日期:2003-08-26 出版日期:2004-08-15 发布日期:2004-08-15
  • 通讯作者: 冉玉平,E-mail:ranyuping@hotmail.com E-mail:ranyuping@hotmail.com
  • 基金资助:
    美国纽约中华医学基金会人力资源青年基金资助(CMB00-722)

Malassezia globosa is the Main Species Found in Hair Follicles of Patients with Malassezia Folliculitis

XIONG Xin-cai, RAN Yu-ping, DAI Ya-lin, XIONG Lin, ZHOU Guang-ping   

  1. Department of Dermato-Venereology, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2003-08-26 Online:2004-08-15 Published:2004-08-15

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摘要： 目的 确定引起马拉色菌毛囊炎的主要菌种,比较皮损毛囊内和毛周表面皮肤菌种是否一致,患者性别、年龄、病情与分离菌种的关系。方法 菜子油培养基培养,根据形态及生理生化特点进行鉴定。结果 从毛周表面皮肤分离的319株菌中鉴定出合轴马拉色菌247株(77.43%)、糠秕马拉色菌40株(12.54%)、球形马拉色菌27株(8.46%)、钝形马拉色菌5株(1.57%);从毛囊内分离的314株菌中鉴定出球形马拉色菌252株(80.25%)、合轴马拉色菌57株(18.15%)、糠秕马拉色菌4株(1.27%)、钝形马拉色菌1株(0.32%),菌种构成差异有显著性(P<0.01)。毛囊内菌种构成与患者的性别和年龄有关,与病情无关。毛囊内和毛周表面皮肤同时阳性的279株中菌种不一致204株,菌种一致75株。结论 马拉色菌毛囊炎毛囊内的主要菌种为球形马拉色菌,其表面皮肤则以合轴马拉色菌为主。

关键词: 毛囊炎, 皮肤真菌病, 马拉色霉菌属

Abstract: Objective To examine the distribution of Malassezia species in follicular contents and perifollicular superficial skin in patients with Malassezia folliculitis and search for its causative agent. Methods A total of 120 patients with Malassezia folliculitis were investigated. Follicular lesions at three different anatomic sites were selected in each patient. Perifolliclar superficial skin specimens were taken by sterile adhesive tape, and the follicular contents of the same follicle were taken by sterile haemostatic forceps. The above specimens were cultured respectively on media containing rapeseed oil. The isolated colonies were identified by their physiological and morphological characteristics. Results Out of 319 isolates obtained from the perifollicular superficial skin, 247 isolates (77.43%) were identified as M. sympodialis, 40 isolates (12.54%) as M. furfur, 27 isolates(8.46%) as M. globosa and 5 isolates(1.57%) as M. obtusa. Out of 314 isolates obtained from follicular contents, 252 isdates(80.25%) were identified as M. globosa, 57 isolates(18.15%) as M. sympodialis, 4 isolates(1.27%) as M. furfur, and 1 isolate(0.32%) as M. obtusa. There was statistical difference in species distribution between the follicular contents and the perifolliclar superficial skin (P<0.01). Correlation analysis showed that there was a correlation between the Malassezia species and the patients' sex and age. In the 279 isolates found in both the follicular contents and the perifolliclar superficial skin, only 75 isolates were identical. Conclusion The principal species of follicular contents of Malassezia folliculitis is M. globosa, but the predominant species on the perifolliclar superficial skin is M. sympodialis.

Key words: Folliculitis, Dermatomycoses, Malassezia