中华皮肤科杂志 ›› 2004, Vol. 37 ›› Issue (10): 601-602.

• 论著 • 上一篇    下一篇

大疱性类天疱疮患者黏膜受累与糖皮质激素控制量的相关性

吴建兵, 崔盘根, 袁艳霞, 林麟, 曹元华   

  1. 中国医学科学院、中国协和医科大学皮肤病研究所 南京 210042
  • 收稿日期:2003-10-07 出版日期:2004-10-15 发布日期:2004-10-15
  • 通讯作者: 崔盘根,E-mail:cuipg@sohu.com E-mail:cuipg@sohu.com

The Corelation of Mucosal Involvement and Corticosteroid Dosage in Bullous Pemphigoid

WU Jian-bing, CUI Pan-gen, YUAN Yan-xia, LIN Lin, CAO Yuan-hua   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China
  • Received:2003-10-07 Online:2004-10-15 Published:2004-10-15

PDF (PC)

64

赞

摘要： 目的 探讨大疱性类天疱疮(bullous pemphigoid,BP)患者黏膜受累与糖皮质激素控制量的相关性。方法 对1988-2002年103例BP住院患者平均糖皮质激素起始控制量、皮损全部消退时间和糖皮质激素开始减量时间进行回顾性研究,按照患者入院时皮损累及部位分为黏膜受累组和无黏膜受累组。结果 103例患者,黏膜受累组37例占35.9%,无黏膜受累组66例占64.1%,黏膜受累组控制病情所需的糖皮质激素量高于无黏膜受累组(t=3.49,P<0.001),两组患者皮损全部消退时间和糖皮质激素首次减量时间差异无显著性(t=0.82和t=0.41,P>0.05)。结论 BP黏膜损害与糖皮质激素控制量相关。

关键词: 类天疱疮, 大疱性, 黏膜, 皮质类甾醇类

Abstract: Objective To study the corelation of mucosal involvement and corticosteroid dosage in the control of bullous pemphigoid(BP). Methods One hundred and three in-patients with bullous pemphigoid hospitalized during 1988-2002 were retrospectively analyzed for their mean corticosteroid dosage for controlling the disease and the duration for complete relieving the skin lesions, as well as the duration to start corticosteroid tapering. All the patients were divided into two groups:group A (37 cases) with mucosal involvement and group B (66 cases) without mucosal involvement. Results The mean corticosteroid dosage used to control the disease in group A was much higher than that in group B (t=3.488, P<0.001). Neither the duration for complete relieving the skin lesions nor the duration to start corticosteroids tapering was significantly different between the two groups (t=0.82 and 0.41, P>0.05). Conclusion Patients with mucosal involvement require a higher dosage of corticosteroids to control the disease.

Key words: Pemphigoid, bullous, Mucosa membrane, Corticosteroids