造血干细胞移植治疗系统性红斑狼疮

摘要/Abstract

摘要： 系统性红斑狼疮(SLE)是一种以多脏器受累和存在多种自身抗体为特征的自身免疫病。近年来,强免疫抑制加造血干细胞移植(hemopoieticstemcelltrans-plantation,HSCT)已成为治疗重症难治性SLE的一种新方法。该疗法以造血干细胞援救清除处理的淋巴或骨髓系统,即以无自身免疫反应性的细胞取代患者自身反应性免疫活性细胞,SLE得到稳定的缓解^[1]。动物实验研究表明SLE的免疫异常主要是造血干细胞异常。动物实验^[2]证实自体或异基因HSCT对动物的佐剂性关节炎和实验性变应性脑脊髓炎都有显著疗效,而临床上血液系统疾病或肿瘤患者接受HSCT后其共存的自身免疫病也得到改善^[3]。

邓俐, 张堂德. 造血干细胞移植治疗系统性红斑狼疮[J]. 中华皮肤科杂志, 2004, 37(11): 682-683.

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