中华皮肤科杂志 ›› 2004, Vol. 37 ›› Issue (11): 651-652.

• 论著 • 上一篇    下一篇

环氧化酶-2在表皮肿瘤中的表达

阮黎明1, 刘国英1, 刘晓艳1, 王丽君2, 严丽萍2, 芦莲治1   

  1. 1. 浙江大学医学院附属第一医院皮肤科 杭州 310003;
    2. 浙江大学医学院附属第一医院病理科 杭州 310003
  • 收稿日期:2003-11-05 出版日期:2004-11-15 发布日期:2004-11-15

The Expression of Cyclooxygenase-2 in Several Epidermal Tumors

RUAN Li-ming1, LIU Guo-ying1, LIU Xiao-yan1, WANG Li-jun2, YAN Li-ping2, LU Lian-zhi1   

  1. Department of Dermatology, First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China
  • Received:2003-11-05 Online:2004-11-15 Published:2004-11-15

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摘要：

目的 探讨环氧化酶-2在不同表皮肿瘤中的表达及意义。方法 选择鳞状细胞癌8例、基底细胞上皮瘤10例、Bowen病8例和脂溢性角化病12例,运用免疫组化方法观察肿瘤细胞中环氧化酶-2的表达。结果 与正常表皮相比,环氧化酶-2在鳞状细胞癌、Bowen病、基底细胞上皮瘤中的表达明显上调,尤其以鳞状细胞癌中的表达最强。而环氧化酶-2在脂溢性角化病中的表达与正常人皮肤的表达近似。结论 环氧化酶-2表达的上调可能在表皮肿瘤的发生发展中发挥一定作用。

关键词: 前列腺素内过氧化物合酶, 癌,鳞状细胞, 癌,基底细胞, Bowen病, 角化病,脂溢性

Abstract:

Objective To explore the expression of cyclooxygenase-2 (COX-2) in different epidermal tumors and its significance.Method The expression of COX-2 was detected by immunohistochemical staining of skin specimens from 10 cases of basal cell carcinoma (BCC),8 squamous cell carcinoma (SCC),8 Bowen's disease (BD),12 seborrheic keratosis (SK) and 10 normal volunteers.Results Compared with normal epidermal cells,COX-2 expression was significantly increased in BCC,SCC and BD cells.Especially,COX-2 expression in SCC was the most intensive.COX-2 expression in SK cells was similar to that of normal epidermal cells.Conclusion The up-regulation of COX-2 expression may play a potential role in the pathogenesis of epidermal tumors.

Key words: Prostaglandin-endoperoxide synthase, Carcinoma,basal cell, Carcinoma,squamous cell, Bowen’s disease, Keratosis,seborrheic