中华皮肤科杂志 ›› 2012, Vol. 45 ›› Issue (8): 586-587.

• 研究报道 • 上一篇    下一篇

皮肤利什曼病六例临床病理分析

刘排1,宋琳毅2,姜祎群3,沈永年3,陈浩3,孙建方3   

  1. 1. 中国医学科学院北京协和医学院皮肤病研究所
    2. 苏州大学附属第一医院皮肤科
    3. 南京 中国医学科学院北京协和医学院皮肤病研究所
  • 收稿日期:2011-09-06 修回日期:2012-02-20 出版日期:2012-08-15 发布日期:2012-08-01
  • 通讯作者: 姜祎群 E-mail:yiqunjiang@yahoo.com.cn

Clinical and pathological analysis of six cases of cutaneous leishmaniasis

  • Received:2011-09-06 Revised:2012-02-20 Online:2012-08-15 Published:2012-08-01
  • Contact: Yi-Qun JIANG E-mail:yiqunjiang@yahoo.com.cn

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摘要：

目的 探讨皮肤利什曼病的流行病学、临床及组织病理学特点。方法 收集并分析6例皮肤利什曼病患者的流行病学、临床及组织病理学资料。结果 6例患者均为男性，平均发病年龄47.67岁（37 ~ 67岁），平均病程10个月（6 ~ 18个月）。皮损特点为红斑、结节、溃疡，分布于面部及四肢暴露部位。组织病理表现为感染性肉芽肿模式，组织标本中均可找到组织细胞胞质内嗜碱性小体。6例患者均具有疫区工作或旅行史。结论 皮肤利什曼病的诊断主要依靠流行病资料、临床表现和组织病理学检查。

关键词: 临床分析

Abstract:

Objective To analyze the epidemiological, clinical and histopathological characteristics of cutaneous leishmaniasis. Methods This study included six patients with cutaneous leishmaniasis diagnosed in the Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, over the past 10 years. The epidemiological features as well as clinical and histopathologic presentations of these patients were analyzed retrospectively. Results All of the six patients were male. The mean age at onset of skin eruptions was 47.67 （range: 37－67） years, and the mean duration of disease was 10 （range: 6－18） months. Clinical presentations included erythema, nodules and ulcers in the face and limbs. Skin biopsy revealed infection-associated granulomatous inflammation with many amastigotes （basophilic bodies） in the cytoplasm of histiocytes, which were highlighted with Giemsa stain. All the patients had a history of working at or travel to epidemic areas. Conclusion The diagnosis of cutaneous leishmaniasis mainly depends on epidemiological data, clinical manifestation and histopathologic findings.

Key words: clinical analysis