中华皮肤科杂志 ›› 2012, Vol. 45 ›› Issue (6): 433-435.

• 研究报道 • 上一篇    下一篇

白癜风患者白介素-17和转化生长因子-β水平的检测

卢娜1,许爱娥2,周妙妮3   

  1. 1. 安徽医科大学附属杭州临床学院
    2. 安徽医科大学附属杭州市第三人民医院皮肤科
    3. 杭州市第三人民医院皮肤科
  • 收稿日期:2011-07-28 修回日期:2012-02-07 出版日期:2012-06-15 发布日期:2012-05-31
  • 通讯作者: 许爱娥 E-mail:xuaiehz@msn.com
  • 基金资助:

    国家自然科学基金资助课题

Measurement of interleukin-17 and transforming growth factor-β in patients with vitiligo

1,   

  • Received:2011-07-28 Revised:2012-02-07 Online:2012-06-15 Published:2012-05-31

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摘要：

【摘要】 目的 探讨白介素-17（IL-17）和 转化生长因子-β（TGF-β）与白癜风发病之间的关系。方法 双抗体夹心酶联免疫吸附试验（ELISA）检测120例白癜风患者和60例健康对照血清中IL-17和TGF-β水平。分析两种因子与白癜风患者性别、病期、病程、白斑面积、家族史的关系。 结果 进展期白癜风患者血清IL-17水平显著高于健康对照组和稳定期患者（P值均 < 0.05），随着白癜风患者白斑面积增大，IL-17水平逐渐升高（χ2 = 12.656，P < 0.05）；而进展期白癜风患者血清TGF-β水平也高于健康对照组和稳定期患者，但差异无统计学意义（P值均 > 0.05）。 结论 白癜风患者血清IL-17和TGF-β水平与病情有一定关系，两者可能在白癜风发病中发挥作用。

关键词: TGF-β

Abstract:

【Abstract】 Objective To assess the relationship of interleukin-17 （IL-17） and transforming growth factor-β （TGF-β） with the development of vitiligo. Methods Enzyme-linked immunosorbent assay （ELISA） was carried out to measure the levels of IL-17 and TGF-β in sera from 120 patients with vitiligo and 60 healthy controls. The correlations of serum IL-17 and TGF-β levels with patients′ gender, stage and duration of disease, involved body area and presence of family history were assessed. Results The level of serum IL-17 was significantly higher in patients with active vitiligo than in the controls and patients with stable vitiligo （both P < 0. 05）. With the rise in involved body area, the level of serum IL-17 gradually increased（χ2 = 12.656, P < 0.05）. The level of TGF-β in patients with active vitiligo was a little higher than that in the controls and patients with stable vitiligo, with no significant difference between these groups （both P > 0.05）. Conclusions The levels of serum IL-17 and TGF-β are somewhat correlated with the activity of vitiligo, and both of them may play a certain role in the pathogenesis of vitiligo.