中华皮肤科杂志 ›› 2012, Vol. 45 ›› Issue (5): 333-336.

• 论著 • 上一篇    下一篇

0.1%他克莫司软膏联合帕罗西汀治疗神经性皮炎的疗效观察

鲍迎秋1,苏闻2,傅裕3   

  1. 1. 北京医院皮肤科
    2. 北京医院神经内科
    3. 卫生部北京医院
  • 收稿日期:2011-11-24 修回日期:2011-12-15 出版日期:2012-05-15 发布日期:2012-05-03
  • 通讯作者: 傅裕 E-mail:fuyu@medmail.com.cn

Clinical efficacy of 0.1% tacrolimus ointment combined with paroxetine for the treatment of neurodermatitis

  • Received:2011-11-24 Revised:2011-12-15 Online:2012-05-15 Published:2012-05-03

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摘要：

目的 探讨0.1%他克莫司软膏联合抗焦虑抑郁药帕罗西汀治疗伴失眠的神经性皮炎的临床疗效。方法 选择74例伴失眠的神经性皮炎患者，按就诊前后顺序以单双数法分为联合组和对照组，两组共同给予0.1%他克莫司软膏外用，其中联合组同时给予口服帕罗西汀10 mg/d共8周治疗，于治疗8周后分别评估两组患者神经性皮炎主要症状、匹兹堡睡眠质量指数问卷评分。最后共67例患者完成观察。结果 联合组与对照组痊愈率分别为54.3％（19/35）、53.1％（17/32），总有效率分别为82.9%（29/35）、 81.3%（26/35），两组之间差异无统计学意义（P ＞ 0.05）。联合组与对照组痊愈后随访3个月的复发率分别为15.8％（3/19）、47.1％（9/17）。联合组痊愈后的复发率明显降低。两组比较差异有统计学意义（P < 0.05）。匹兹堡睡眠质量指数评分治疗8周后联合组得分明显低于对照组，两组比较差异有统计学意义（P < 0.05）。结论 0.1%他克莫司软膏可以安全用于神经性皮炎。抗焦虑治疗可降低伴失眠的神经性皮炎的复发率，同时提高患者睡眠质量。

关键词: 联合治疗

Abstract:

Objective To evaluate the clinical efficiency of 0.1% tacrolimus ointment combined with paroxetine in patients with neurodermatitis associated with insomnia. Methods Totally, 74 patients suffering from neurodermatitis and insomnia were consecutively enrolled in this study, and randomly assigned into the combination group and control group according to their number （odd or even）. Both groups were given topical 0.1% tacrolimus ointment twice a day, and the combination group was additionally given oral paroxetine 10 mg once a day, for 8 weeks. The outcome parameters included main symptoms of neurodermatitis and Pittsburgh sleep quality index （PSQI） score. Results No significant difference was observed in the cure rate （54.3％ （19/35） vs. 53.1％ （17/32）, P > 0.05） or response rate （82.9% （29/35） vs. 81.3% （26/32）, P > 0.05）, between the combination group and control group. PSQI score was significantly lower in the combination group than in the control group after 8 weeks of treatment （P < 0.05）. Conclusions The 0.1% tacrolimus ointment can be used to treat neurodermatitis safely. Antianxiety treatment can reduce the recurrence of neurodermatitis associated with insomnia, and improve the quality of sleep in patients.

Key words: Combined treatment