参考文献 1. Packiam M, Veit SJ, Anderson DJ, et al.Mouse strain-dependent differences in susceptibility to Neisseria gonorrhoeae infection and induction of innate immune responses. Infect Immun. 2010 ;78(1):433-40. 2. David N. Quan, Morris D. Cooper, Jamie L. Potter, et al.TREM-2 Binds to Lipooligosaccharides of Neisseria gonorrhoeae and is Expressed on Reproductive Tract Epithelial Cells. Mucosal Immunol. 2008 ; 1(3): 229–238 3. Duncan JA, Gao X, Huang MT, et al. Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome. J Immunol. 2009 15;182(10):6460-9. 4. Ngampasutadol J, Tran C, Gulati S, et al. Species-specificity of Neisseria gonorrhoeae infection: do human complement regulators contribute? Vaccine. 2008 ;26 Suppl 8:I62-6. 5. Hedges SR,Mayo MS,Mestecky J,et al. Limited local and systemic antibody responses to Neisseria gonorrhoeae during uncomplicated genital infections. Infect Immun. 1999; 67(8): 3937-3946 6. Schmidt KA, Schneider H, Lindstrom JA, et al. Experimental gonococcal urethritis and reinfection with homologous gonococci in male volunteers. Sex Transm Dis. 2001;28(10):555-564 7. Song WX, Condron S, Mocca BT, et al. local and humoral immune responses against primary and repeat Neisseria gonorrhoeae genital tract infections of 17β-estradiol-treated mice. Vaccine 2008; 26(45):5741-5751 8. Imarai, M., E. Candia, C. Rodriguez-Tirado, et al. Regulatory T cells are locally induced during intravaginal infection of mice with Neisseria gonorrhoeae. Infect. Immun. 2008; 76:5456–5465. 9. Feinen B, Jerse AE, Gaffen SL, et al. Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection. Mucosal Immunol. 2010 Jan 27. [Epub ahead of print] 10. van Vliet SJ, Steeghs L, Bruijns SC et al. Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses. PLoS Pathog. 2009 ;5(10):e1000625. 11. Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance 2007 Supplement, Gonococcal Isolate Surveillance Project (GISP) Annual Report 2007. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, March 2009 12. Australian Gonococcal Surveillance Programme, Tapsall J. Annual report of the Australian Gonococcal Surveillance Programme, 2008. Commun Dis Intell. 2009 ;33(3):268-74. 13. Chisholm SA, Neal TJ, Alawattegama AB, et al. Emergence of high-level azithromycin resistance in Neisseria gonorrhoeae in England and Wales.J Antimicrob Chemother. 2009;64(2):353-8. 14. Tzelepi E, Avgerinou H, Flemetakis A,Changing figures of antimicrobial susceptibility and serovar distribution in Neisseria gonorrhoeae isolated in Greece. Sex Transm Dis. 2010 ;37(2):115-20. 15. de Vries HJ, van der Helm JJ, Schim van der Loeff MF, et al. Multidrug-resistant Neisseria gonorrhoeae with reduced cefotaxime susceptibility is increasingly common in men who have sex with men, Amsterdam, the Netherlands. Euro Surveill. 2009;14(37). pii: 19330 16. Unemo M, et al. Phenotypic and genetic characterization of the 2008 WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance (AMR) surveillance for public health purposes. Journal of Antimicrobial Chemotherapy 2009; 63: 1142–1151. 17. Ison CA, Martin IM, Lowndes CM, et al. Comparability of laboratory diagnosis and antimicrobial susceptibility testing of Neisseria gonorrhoeae from reference laboratories in Western Europe. Journal of Antimicrobial Chemotherapy 2006; 58: 587–593 18. Bala M, Tapsall JW, Limnios A, et al. Experience with an external quality assurance scheme for antimicrobial susceptibility testing of Neisseria gonorrhoeae in India, 2001-2007. Epidemiol Infect. 2010 ;138(1):69-75. 19. Ito M, Deguchi T, Mizutani KS et al. Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillinbinding protein 2 in Central Japan. Antimicrob Agents Chemother 2005; 49(1):137-43. 20. Tapsall JW, Ray S, Limnios A.Characteristics and population dynamics of mosaic penA allele-containing Neisseria gonorrhoeae isolates collected in Sydney, Australia, in 2007-2008. Antimicrob Agents Chemother. 2010 ;54(1):554-6. 21. Pandori M, Barry PM, Wu A, et al. Mosaic penicillin-binding protein 2 in Neisseria gonorrhoeae isolates collected in 2008 in San Francisco, California. Antimicrob Agents Chemother. 2009 ;53(9):4032-4. 22. Ohnishi M, Watanabe Y, Ono E, et al. Spreading of a chromosomal cefixime resistant penA gene among different Neisseria gonorrhoeae lineages. Antimicrob Agents Chemother. 2009 ; Dec 22. [Epub ahead of print] 23. Zhao S, Duncan M, Tomberg J, et al. Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2009 ;53(9):3744-51. 24. Sang-Guk Lee, Hyukmin Lee, Seok Hoon Jeong， et al. Various penA mutations together with mtrR, porB and ponA mutations in Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime or ceftriaxone. J Antimicrob Chemother. 2010 ；Jan 21. [Epub ahead of print] 25. Unemo, M., P. Olce′n, J. Albert, and H. Fredlund. Comparison of serologic and genetic porB-based typing of Neisseria gonorrhoeae: consequences for future characterization. J. Clin. Microbiol. 2003; 41:4141–4147. 26. Viscidi, R. P., and J. C. Demma. Genetic diversity of Neisseria gonorrhoeae housekeeping genes. J. Clin. Microbiol. 2003; 41:197–204. 27. Martin, I., C. Ison, D. Aanensen, K. Fenton, and B. Spratt. 2004. Rapid sequence-based identification of gonococcal transmission clusters in a large metropolitan area. J. Infect. Dis. 189:1497–1505. 28. Mingmin Liao, Sarah Helgeson, Wei-Ming Gu, et al. Comparison of Neisseria gonorrhoeae Multiantigen Sequence Typing and porB Sequence Analysis for Identification of Clusters of N. gonorrhoeae Isolates。J Clin Microbiol 2009;47(2) :489–491 29. Julia S Bennett, Keith A Jolley, P Frederick Sparling,et al. Species status of Neisseria gonorrhoeae: evolutionary and epidemiological inferences from multilocus sequence typing。 BMC Biology 2007;5:35 30. Choudhury B, Risley CL, Ghani AC, et al. Identification of individuals with gonorrhoea within sexual networks: a population-based study. Lancet. 2006 ;368(9530):139-46. 31. Unemo M, Sj?strand A, Akhras M, et al. Molecular characterization of Neisseria gonorrhoeae identifies transmission and resistance of one ciprofloxacin-resistant strain. APMIS. 2007 ;115(3):231-41. 32. Bilek N, Martin IM, Bell G,et al. Concordance between Neisseria gonorrhoeae genotypes recovered from known sexual contacts. J Clin Microbiol. 2007 ;45(11):3564-7. 33. Whiley DM, Goire N, Ray ES, et al. Neisseria gonorrhoeae Multi-Antigen Sequence Typing using non-cultured clinical specimens. Sex Transm Infect. 2009; 86(1):51-5. 34. Zhu W, Thomas CE, and Sparling PE.DNA immunization of mice with a plasmid encoding Neisseria gonorrhoeae PorB protein by intramuscular injection and epidermal particle bombardment. Vaccine 2004;22:660-669 35. Zhu W, Thomas CE, Chen C, et al. comparison of Immune responses to gonococcal PorB delivered as outer membrane vesicles, recombinant protein, or Venezuelan Equine Encephalitis virus replicon particles. Infect Immun.2005;73(11):7558-7568 36. Price GA, Russell MW, and Cornelissen CN. Intranasal administration of recombinant Neisseria gonorrhoeae transferring binding proteins A and B conjugated to the cholera toxin B subunit induces systemic and vaginal antibodies in mice. Infect Immun. 2005; 73(7): 3945-3953 37. Price GA, Masri HP, Hollander AM, et al. Gonococcal transferring binding protein chimeras induce bactericidal and growth inhibitory antibodies in mice. Vaccine 2007; 25(41):7247-7260 38. Ngampasutadol J, Rice PA, Walsh MT, et al. Characterization of a peptide vaccine candidate mimicking an oligosaccharide epitope of Neisseria gonorrhoeae and resulotant immune responses and function. Vaccine 2006;24（2）：157-170 39. Su X,Ngampasutadol J,Zheng B,et al. Vaccination with a gonococcal oligosaccharide epitope configured as a peptide mimic fused with complement component C3d. In: Abstracts of the Sixteenth International pathogenic Neisseria Conference (Rotterdam),2008:P186 40. Su X, Ngampasutadol J, Zheng B,et al. Exploitation of fungal mannosylation to boost immunogenicity in mice of a peptide vaccine candidate that mimics an oligosaccharide epitope of Neisseria gonorrhoeae. In: Abstracts of the Sixteenth International pathogenic Neisseria Conference (Rotterdam),2008:P187