中华皮肤科杂志 ›› 2012, Vol. 45 ›› Issue (2): 127-128.

• 研究报道 • 上一篇    下一篇

神经生长因子及其受体TrkA、p75NTR在隆凸性皮肤纤维肉瘤和皮肤纤维瘤中的表达

钱悦1,张娜2,陈思远3,褚淑娟4,冯爱平5   

  1. 1. 武汉协和医院皮肤科
    2.
    3. 武汉市华中科技大学同济医学院附属协和医院皮肤科
    4. 华中科技大学同济医学院协和医院麻醉科
    5. 武汉市协和医院皮肤科
  • 收稿日期:2011-03-29 修回日期:2011-09-15 出版日期:2012-02-15 发布日期:2012-01-31
  • 通讯作者: 冯爱平 E-mail:arzt@tom.com
  • 基金资助:

    携带MIA 基因减毒LM 抑制恶性黑素瘤增殖与诱导免疫效应的研究

Expressions of nerve growth factor and its receptors TrkA and p75NTR in dermatofibrosarcoma protuberans and dermatofibroma

  • Received:2011-03-29 Revised:2011-09-15 Online:2012-02-15 Published:2012-01-31

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摘要：

目的 探讨神经生长因子（NGF）及其受体酪氨酸激酶A （TrkA）、p75神经营养因子受体（p75NTR）在隆凸性皮肤纤维肉瘤和皮肤纤维瘤中的表达。 方法 应用免疫组化ABC法检测隆凸性皮肤纤维肉瘤石蜡标本17例、皮肤纤维瘤石蜡标本15例中NGF及其受体TrkA、p75NTR表达。 结果 NGF及TrkA 在隆凸性皮肤纤维肉瘤及皮肤纤维瘤中均呈高表达, 两者之间差异无统计学意义（χ2 = 0.11,0.02, P值均 > 0.05）；而p75NTR在隆凸性皮肤纤维肉瘤中的表达显著高于皮肤纤维瘤 （χ2 = 32，P < 0.01），且 NGF与p75NTR在隆凸性皮肤纤维肉瘤表达呈正相关（R2 = 0.623, P < 0.01）。 结论 NGF可能通过其高亲和受体TrkA及低亲和受体p75NTR在隆凸性皮肤纤维肉瘤的发病中起一定作用。

关键词: 神经生长因子

Abstract:

Objective To investigate the expressions of nerve growth factor （NGF） and its receptors TrkA and p75NTR in dermatofibrosarcoma protuberans and dermatofibroma. Methods Avidin-biotin immunohistochemical （ABC） method was used to detect the expressions of NGF and its receptors TrkA and p75NTR in paraffin-embedded tissue specimens from 17 cases of DFSP and 15 cases of dermatofibroma. Results NGF and TrkA were highly expressed in both DFSP and dermatofibroma specimens, with no significant difference between the two groups of specimens （?字2 = 0.11, 0.02, respectively, both P > 0.05）, while the expression of p75NTR was significantly higher in DFSP than in dermatofibroma specimens （?字2 = 32, P < 0.01）. The expression of NGF was positively correlated with that of p75NTR in DFSP （R2 = 0.623, P < 0.01）. Conclusion NGF may play a certain role in the development of DFSP via its high-affinity receptor TrkA and low-affinity receptor p75NTR.

Key words: Nerve growth factor