关键词: 壳聚糖

Abstract:

Objective To study the promotive effect of chitosan liquid on wound healing. Methods Wound model was established on the back of 60 rats, which were classified into 3 groups to be treated with topical chitosan liquid （group A）, basic fibroblast growth factor （group B）, and sodium chloride physiological solution （group C）, respectively. The time required for the healing of wound was recorded. Regenerated tissues were resected from the rats on day 3, 7 and 14 after the establishment of wound model, and observed with light microscopy. Results The time required for the healing of wound was 17.3 ± 1.35 days in group A, 18.2 ± 1.15 days in group B, and 24.0 ± 1.37 days in group C. For the time required for the healing of wound, no significant difference was observed between the group A and B （P > 0.05）, but group C significantly differed from group A and B （both P < 0.05）. Chitosan liquid accelerated the generation of capillary sprouts and vascular endothelial cells at the early stage of wound healing, promoted the production of fibroblasts and collagen fibers at the middle stage, and improved the organization of collagen fibers at the late stage. Conclusion Chitosan liquid exerts a promising promotive effect on wound healing.