中华皮肤科杂志 ›› 2011, Vol. 44 ›› Issue (8): 594-595.

• 研究报道 • 上一篇    下一篇

308 nm准分子光治疗稳定期白癜风的疗效观察

尹锐1,邓军2,杨希川1,周村建3,郝飞1,林琳1,肖艳4,5   

  1. 1. 重庆第三军医大学西南医院皮肤科
    2. 第三军医大学附属西南医院皮肤科
    3. 重庆市第三军医大学西南医院
    4. 第三军医大学西南医院皮肤科
    5.
  • 收稿日期:2010-12-24 修回日期:2011-06-02 出版日期:2011-08-15 发布日期:2011-07-26
  • 通讯作者: 郝飞 E-mail:haofei62@medmail.com.cn

Efficacy of 308-nm excimer light in the treatment of stable vitiligo

  • Received:2010-12-24 Revised:2011-06-02 Online:2011-08-15 Published:2011-07-26
  • Contact: Hao Fei E-mail:haofei62@medmail.com.cn

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摘要：

目的 观察308 nm准分子光治疗稳定期白癜风的疗效和安全性。方法 对30例稳定期白癜风患者采用国产308 nm准分子光治疗，每周照射2次，每月观察1次，连续观察3个月。结果 治疗后30例患者面颈、躯干、四肢皮损复色的总有效率分别为95.0%、75.0%、66.7%，平均治疗次数分别为（10.22 ± 1.60）次、（19.10 ± 2.38）次、（37.74 ± 3.06）次，三者两两比较差异均具有统计学意义（P值均 < 0.05）。平均累积照射剂量面颈部、躯干部和四肢依次为（7.50 ± 3.45）、（10.60 ± 1.01）、（18.56 ± 3.05） J/cm2。所有患者在治疗过程中均未出现严重不良反应。结论 国产308 nm准分子光治疗白癜风有效而且安全。

关键词: 安全性

Abstract:

Objective To evaluate the efficacy and safety of 308-nm excimer light in the treatment of stable vitiligo. Methods Thirty patients with stable vitiligo were enrolled in this clinical trial. All the subjects received the treatment with 308-nm excimer light on a twice-weekly schedule for 3 months. Results The repigmentation rate was 95.0%, 75.0% and 66.7% for lesions in the face and neck, trunk and limbs, with the treatment sessions averaging 10.22 ± 1.60, 19.10 ± 2.38, 37.74 ± 3.06, respectively, and accumulative irradiation dose averaging 7.50 ± 3.45, 10.60 ± 1.01, 18.56 ± 3.05 J/cm2 respectively. Significant differences were observed in the repigmentation rate and treatment sessions between the lesions in the face and neck, trunk and limbs （all P < 0.05）. No severe side effects were seen during the treatment. Conclusion 308-nm excimer light is effective and safe for the treatment of vitiligo.

Key words: safety