中华皮肤科杂志 ›› 2011, Vol. 44 ›› Issue (8): 589-590.

• 研究报道 • 上一篇    下一篇

尖锐湿疣患者治疗前后血清白介素24、干扰素γ和白介素4水平的检测

李春霞1,李永喜2,尉莉1,毕建平3,3,张建明1,3   

  1. 1. 青岛市市立医院皮肤科
    2. 青岛市市立医院
    3.
  • 收稿日期:2010-10-06 修回日期:2011-02-16 出版日期:2011-08-15 发布日期:2011-07-26
  • 通讯作者: 尉莉 E-mail:bellewli@yahoo.com.cn

Determination of serum levels of interleukin （IL）-24, interferon （IFN）-γ and IL-4 in patients with condyloma acuminatum before and after treatment

  • Received:2010-10-06 Revised:2011-02-16 Online:2011-08-15 Published:2011-07-26

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摘要：

目的 研究尖锐湿疣患者治疗后血清白介素24（IL-24）、干扰素γ（IFN-γ）和白介素4（IL-4）水平变化。方法 采用双抗体夹心酶联免疫吸附法分别检测了42例尖锐湿疣患者在治疗前和治疗痊愈3个月后血清IL-24、IFN-γ和IL-4的水平，35例正常人作为对照。结果 尖锐湿疣患者治疗前血清IFN-γ明显低于正常人对照组，IL-4、IL-24水平明显高于正常人对照组；治疗痊愈3个月后三者同正常人对照组无明显差异。结论 尖锐湿疣患者体内细胞免疫功能受损，可能在尖锐湿疣发病中起一定作用。

关键词: 白细胞介素4

Abstract:

Objective To investigate the changes of serum levels of IL-24, IFN-γ and IL-4 in patients with condyloma acuminatum （CA） after treatment. Methods Forty-two patients with CA who experienced no recurrence within 3 months after successful treatment were enrolled in this study. Double-antibody sandwich enzyme-linked immunoabsorbent assay （DAS ELISA） was performed to determine the serum levels of IL-24, IFN-γ and IL-4 in these patients before and 3 months after successful treatment as well as in 35 normal human controls. Results The untreated patients showed a lower level of serum IFN-γ （9.65 ± 3.70 vs. 15.49 ± 3.85 ng/L, P < 0.01） and a higher level of serum IL-4 and IL-24 （15.91 ± 6.14 vs. 10.48 ± 5.08 ng/L, 141.84 ± 44.01 vs. 103.20 ± 41.37 ng/L, both P < 0.01） compared with the controls. No significant difference was observed for the above parameters between the serum samples from the controls and patients 3 months after successful treatment. Conclusions Cellular immunity is impaired in patients with CA, which may be involved in the immunopathogenesis of CA.

Key words: Interleukin-4