中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (11): 814-814.

• 短篇论著 • 上一篇    下一篇

p75神经营养因子受体在鳞状细胞癌中的表达

邬运学1,田华*2,何荣国3,武钦学4,张燕妮3,黄葵4   

  1. 1. 广州市第十二人民医院
    2. 广州市第十二医院皮肤科
    3. 广州市第十二人民医院皮肤科
    4.
  • 收稿日期:2010-03-02 修回日期:2010-06-19 出版日期:2010-11-15 发布日期:2010-11-10
  • 通讯作者: 邬运学 E-mail:birdbyah@yahoo.com.cn
  • 基金资助:

    广东省医学科技项目;广州市医药卫生科技项目

Expression of p75 neurotrophin receptor in squamous cell carcinoma

  • Received:2010-03-02 Revised:2010-06-19 Online:2010-11-15 Published:2010-11-10

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摘要：

[摘要] 　目的：探讨p75神经营养因子受体在鳞状细胞癌中的表达及意义。方法：用原位杂交法检测15例鳞状细胞癌、13例正常皮肤中p75神经营养因子受体。结果： p75神经营养因子受体在正常皮肤中的表达明显高于鳞状细胞癌，其差异有显著性(t=2.095, P<0.05)。结论：p75神经营养因子受体的低表达可能以量依赖模式影响鳞状细胞癌的发生发展。

关键词: [关键词] 鳞状细胞癌, p75神经营养因子受体, 表达

Abstract:

【Abstract】　Objective　To investigate expression and significance of p75 neurotrophin receptor (p75NTR) in squamous cell carcinoma (SCC). Methods　The expression of p75NTR was measured by in situ hybridization with paraffin sections of 28 skin samples consisted of 15 cases of SCC，and 13 cases of normal skin (NS). In this subject, brain tissue and neuroblastoma were chose as positive culture, and PBS was used instead of hybridization fluid as negative culture. Results　Expression of p75NTR was lower in SCC than in NS, and the significant difference was existent between them (t=2.095, P<0.05). In the two groups of samples, the different distribution of p75NTR was distinct, that p75NTR was principally present in carcinoma cells based on SCC, in basal cells originated from NS, and in "normal" peri-SCC tissue with non- or micro-expression. Conclusions　Low expression of p75NTR may played an important role to drive the appearance and exacerbation of SCC in a possible quantity-dependent manner, and the results could be represented as the outcomes of self-disintegration of p75NTR in different sections with different speed.

Key words: 【Key words】 squamous cell carcinoma, p75 neurotrophin receptor, expression