中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (10): 733-734.

• 短篇论著 • 上一篇    下一篇

日常暴露日光改变表皮通透屏障功能稳态动力学及角质层的致密性

刘之力1,孙铮2,王皓2,Peter M Elias3,蔄茂强4   

  1. 1. 大连市皮肤病医院激光美容科
    2.
    3. Dermatology, UCSF, USA
    4. Dermatology,University of California San Frnacisco and NCIRE
  • 收稿日期:2009-10-30 修回日期:2010-07-08 出版日期:2010-10-15 发布日期:2010-10-09
  • 通讯作者: 蔄茂强 E-mail:maoqiangman@hotmail.com
  • 基金资助:

    2008中华医学会－薇姿皮肤医学研究基金

Daily sun exposure alters epidermal permeability barrier homeostasis and stratum corneum integrity

  • Received:2009-10-30 Revised:2010-07-08 Online:2010-10-15 Published:2010-10-09
  • Contact: Mao-Qiang Man E-mail:maoqiangman@hotmail.com

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摘要：

目的 确定日常暴露日光是否影响表皮通透屏障功能及角质层的致密性。材料和方法 共325例志愿者，年龄15-59岁（男160例、女165例；平均年龄28.6 + 0.62）参加本项研究。根据过去连续5天每天直接暴露日光的时间分为4组。无直接日光暴露或日暴露时间少于1hr为对照组；每日直接日光暴露时间1-2hr，而且11:00AM至1:00PM无直接日光暴露为少量日光暴露组；每日直接日光暴露时间大于2hr，少于4hr，包括11:00AM至1:00PM直接日光暴露为中量日光暴露组；每日直接日光暴露4-6hr，包括11:00AM至1:00PM直接日光暴露为大量日光暴露组。利用Courage-Khazaka多功能皮肤生理仪TM300及CM825探头分别测量透皮水分丢失率和角质层的含水量（电容）。结果：与对照组相比较，少量日光暴露组角质层的致密性降低，而中量和大量日光暴露组角质层的致密性没有明显改变；少量日光暴露组角质层的致密性也明显低于中量和大量日光暴露组。中量和大量日光暴露组的表皮通透屏障功能恢复率明显降低。与对照组相比，日常日光暴露对角质层的含水量没有明显影响。结论 日常日光暴露可影响角质层的致密性及表皮通透屏障功能的稳态动力学。

关键词: 紫外线、角质层、通透屏障功能、致密性、角质层含水量

Abstract:

Objective To determine whether daily sun exposure impacts epidermal permeability barrier function, stratum corneum integrity and stratum corneum hydration. Materials and Methods Total 325 volunteers aged 15-59 years (160 males and 165 females; mean age 28.6 + 0.62) were enrolled in this study. According to their daily direct sun exposure time in last five days, subjects were divided into a).control group whose daily direct sun exposure time was less than 1 hour and without direct sun exposure between 11:00am to 1:00pm; b). lower dosage sun exposed group whose daily direct sun exposure time was 1-2 hours and without direct sun exposure between 11:00am to 1:00pm; c). medium dosage sun exposed group whose daily direct sun exposure time was more than 2 hours, but less than 4 hours with direct sun exposure between 11:00am to 1:00pm; and d). higher dosage sun exposed group whose daily direct sun exposure time was 4-6 hours and with direct sun exposure between 11:00am to 1:00pm. Transepidermal water loss and stratum corneum capacitance were measured with a TM300 and CM825 probes, respectively, connected to MPA5 skin physiology monitor. Results In comparison with control group, lower dosage sun exposure decreases stratum corneum integrity. Moreover, stratum corneum integrity in lower dosage sun exposed group is inferior to those in medium and higher dosage sun exposed groups. However, barrier recovery rate is significantly delayed in both medium and higher dosage sun exposed groups. Additionally, there is no change in stratum corneum hydration in comparison with control. Conclusions daily sun exposure impacts epidermal permeability barrier function and stratum corneum integrity.

Key words: UV, Stratum Corneum, Permeability Barrier Function, Integrity, stratum corneum hydration