中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (6): 427-428.

• 短篇论著 • 上一篇    下一篇

α-甲酰基辅酶A消旋酶在原发性乳房外Paget病中的表达

薛燕宁1,曾学思1,陈浩1,顾黎雄2,李阿梅3,邵雪宝1,孙建方1   

  1. 1. 南京 中国医学科学院北京协和医学院皮肤病研究所
    2. 南通大学附属医院
    3. 南京市 中国医学科学院皮肤病研究所
  • 收稿日期:2009-09-03 修回日期:2009-09-29 出版日期:2010-06-15 发布日期:2010-06-08
  • 通讯作者: 薛燕宁 E-mail:xyning52@163.com
  • 基金资助:

    江苏省自然科学基金

Expression of alpha-methylacyl-CoA racemase in tissue of extramammary paget’s disease

  • Received:2009-09-03 Revised:2009-09-29 Online:2010-06-15 Published:2010-06-08

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摘要：

目的 研究α-甲酰基辅酶A消旋酶（AMACR）在原发性乳房外Paget病中表达的特点及意义。 方法 免疫组化法检测AMACR在30例原发性乳房外Paget病中的表达。 结果 30例原发性EMPD中17例AMACR表达阳性，阳性率为56.7%。 结论 AMACR在原发性EMPD中有较高的阳性率，对诊断有所帮助，但AMACR不能作为鉴别原发性和继发性EMPD的免疫组化标记物。

关键词: α-甲酰基辅酶A消旋酶, 佩吉特病，乳腺外

Abstract:

Objective To investigate the expression of AMACR in primary extramammary Paget’s disease. Methods By using immunohistochemical methods, we examined the expression of AMACR on formalin-fixed paraffin-embedded tissue samples from 30 patients with EMPD without associated visceral mallignant noplasms or adnexal carcinoma. Results AMACR was indentified in 17 of 30 cases. The AMACR expression rate of EMPD was 56.7%. Conclusions AMACR can’t be a special maker for distinguish of primary and secondary EMPD.

Key words: AMACR, Pagets disease, extramammary