中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (5): 366-367.

• 临床经验 • 上一篇    下一篇

光动力联合电灼治疗尖锐湿疣222例

朱林榆1,陈彬2,宣暄3,李秉煦4   

  1. 1. 温州医学院附属第一医院皮肤性病科
    2. 温州医学院附属第一医院
    3.
    4. 温州医学院附属第一医院皮肤科
  • 收稿日期:2009-04-27 修回日期:2009-05-18 出版日期:2010-05-15 发布日期:2012-04-12
  • 通讯作者: 朱林榆 E-mail:xfmcl2003@yahoo.com.cn

Photodynamic therapy plus electrical cautery in the treatment of 222 cases of condyloma acuminatum

  • Received:2009-04-27 Revised:2009-05-18 Online:2010-05-15 Published:2012-04-12
  • Contact: ZHU Lin-yu E-mail:xfmcl2003@yahoo.com.cn

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摘要：

【摘要】 目的 观察5-氨基酮戊酸光动力疗法（ALA-PDT）治疗尖锐湿疣(CA)的临床疗效，以及ALA-PDT治疗后复发率与人乳头瘤病毒（HPV）分型（高危型、低危型）的关系。方法 电灼组：87例，用电灼去除疣体；联合组：90例，先用电灼去除疣体，再续以每周1次共4次的ALA-PDT治疗；ALA-PDT组：103例，只给予每周1次，共4次ALA-PDT。其中治电灼组、联合组进行HPV DNA检测，将其分为高危型和低危型两组。结果 电灼组、联合组以及ALA-PDT组的治愈率、复发率分别为100%、66.67%，100%、8.89 %，68.93%、21.13%；三组的治愈率与复发率均进行两两比较，差异均具有统计学意义（P<0.05）（除电灼组与联合组相等外）。电灼组的高危型、低危型复发率分别为85.71%、58.62%，两者差异有统计学意义（P<0.05）；联合组高危型和低危型复发率分别13.04%、8.33%,差异无统计学意义（P>0.05）。结论 电灼和联合组治愈率相同且高于单纯ALA-PDT组，电灼复发率最高，联合组复发率最低，单纯ALA-PDT组副作用最小；光动力疗法可能对HPV高危亚型更敏感。

关键词: 电凝术

Abstract:

【Abstract】 Objective To observe the cure and recurrence rate of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating condyloma acuminatum (CA) and the relation between the recurrence rate and HPV classification(high-risk、low-risk). Methods All the enrolled patients after being diagnosed with CA were divided into three treatment groups (electrocagulation group: 87cases, combined theray group: 90cases, ALA-PDT group:103 cases) at random . The electrocagulation group was treated with electrocagulation; the combined theray group was treated with electrocagulation and followed by ALA-PDT weekly for 4 times;the ALA-PDT group was received only ALA-PDT therapy, also weekly for 4 times under the same parameter as the treatment of the combined theray group. At the same time ，the each verruca samples from the patients in the electrocagulation group and combined theray group was detected HPV DNA and then the results of viral types of HPV were classified into high-risk group and low-risk group.Results the cure and recurrent rate was 100%、 66.67% ，100%、8.89% and 68.93%、21.13% for three treatment groups respectively；the difference was statistically significant between the every two groups among three treatment groups (P<0.05). The recurrent rate for high-risk group and low-risk group in the electrocagulation group and combined theray group was 85.71%、58.62%，13.04%、8.33% respectively；the difference was statistically significant in the electrocagulation group(P<0.05)and no statistically significant difference was found between in the combined theray group(P>0.05). Conclusion The cure rate in the electrocagulation group was the same as combined theray group and was much higher than the ALA-PDT group ,moreover the recurrence rate was the lowst in the combined theray group,while the recurrence rate of the electrocagulation group was the highest among three treatment groups.The side-effect from the simple ALA-PDT group was the lowest than other two groups.The recurrence rate for high-risk group was probably decreased significantly after patients was treated with ALA-PDT.