中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (1): 55-55.

• 短篇论著 • 上一篇    下一篇

慢性特发性荨麻疹与瘦素水平的相关性研究

金外淑1,夏秀娟2,王福胜3,康尔恂1,郑海波4,巫毅5   

  1. 1. 烟台毓璜顶医院
    2. 山东烟台市毓璜顶医院
    3. 山东省烟台市毓璜顶医院
    4.
    5. 长春市吉林大学第二医院皮肤科
  • 收稿日期:2009-02-03 修回日期:2009-03-05 出版日期:2010-01-15 发布日期:2010-01-05
  • 通讯作者: 金外淑 E-mail:jinwaishu@sohu.com
  • 基金资助:

    无

Correlation analysis between chronic idiopathic urticaria and leptin levels

  • Received:2009-02-03 Revised:2009-03-05 Online:2010-01-15 Published:2010-01-05

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摘要：

目的 探讨慢性特发性荨麻疹(CIU)与瘦素水平的相关性。方法 对45例CIU患者做了自体血清皮肤试验（ASST），根据结果分为ASST阳性组及ASST阴性组，对CIU各组与32例正常对照组之间，采用放射免疫技术检测其血清瘦素水平，并进行比较。结果 （1）45例CIU患者中ASST阳性率为37.78%。（2）CIU患者血清瘦素水平（12.51士4.29ng/ml）较正常对照（15.57士4.38ng/ml）显著降低（P<0.01）。（3）与正常对照（15.57士4.38ng/ml）比较，ASST阳性组（11.30士4.41ng/ml）及ASST阴性组（13.23士4.13ng/ml）血清瘦素水平分别显著降低(P值分别为0.002，0.039)；而ASST阳性组与ASST阴性组间瘦素水平无显著性差异（P>0.05）。结论 CIU患者瘦素水平下降，瘦素可能在CIU的发生发展中起作用。

关键词: 慢性特发性荨麻疹；瘦素；自体血清皮肤试验

Abstract:

Objective The aim of this study is to explore the relationship between Chronic idiopathic urticaria（CIU）and the level of serum leptin. Methods　Autologous Serum Skin Test (ASST) was used in 45 patients of CIU and CIU patients were divided into ASST positive group and ASST negative group according the results from the test. The level of serum leptin was detected by radioimmunoassay in CIU group and healthy control group that matched each other in age, gender and BMI and included 32 persons . Results　(1)The positive rate of ASST was 31.78% in 45 patients. (2) The leptin level of CIU group (12.51士4.29ng/ml)was significantly lower than that of control group(15.57士4.38ng/ml)(P<0.01). (3)Both positive and negative ASST group’s leptin level was significantly lower than that of control group (P=0.002, P=0.039), but there was no significant difference between the positive ASST group and negative one(P>0.05). Conclusions　The level of serum leptin is low in CIU patients, therefore, leptin could play an important role in the pathogenesy of CIU.