中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (1): 18-21.

• 论著 • 上一篇    下一篇

系统性硬皮病患者血清抗核抗体与临床表现的相关性研究

孙秋宁1,杜伟2,赵党生3,等3   

  1. 1. 北京协和医院皮肤科
    2. 北京协和医院
    3.
  • 收稿日期:2009-05-22 修回日期:2009-08-26 出版日期:2010-01-15 发布日期:2010-01-05
  • 通讯作者: 孙秋宁 E-mail:doctorjenny1@126.com

Relationship between serum antinuclear antibodies and clinical manifestations in patients with systemic sclerosis

  1. 1.
    2. Peking Union Medical College Hospital
  • Received:2009-05-22 Revised:2009-08-26 Online:2010-01-15 Published:2010-01-05

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摘要：

目的 探讨系统性硬皮病（SSc）患者血清自身抗体与临床之间的关系。方法 对1981—2009年确诊为系统性硬皮病的283例患者的临床资料进行分析。结果 283例患者中，女253例（89.4%），平均发病年龄（35.9 ± 12.6）岁，就诊时平均病程（4.3 ± 4.5）年。弥漫性皮肤型SSc共125例（44.2%）。ANA阳性96.8%，抗Scl-70抗体阳性54.4%，ACA阳性6.4%，抗RNP阳性23.7%，抗Sm抗体阳性7.1%，抗SSA抗体阳性25.1%，抗SSB抗体阳性7.1%，抗Jo-1抗体阳性1.1%，未检出抗rRNP抗体。抗Scl-70抗体、ACA均阳性者仅1例。在lcSSc中ACA阳性率较dcSSc中高（P < 0.05）。结论 抗核抗体检测有助于对SSc患者进行诊断、分型、预后及处理。

关键词: 硬皮病，系统性, 抗体，抗核, 回顾性研究

Abstract:

Objective To investigate the clinical relevance of antinuclear antibodies （ANA） in patients with systemic sclerosis（SSc）. Methods Clinical data were collected from 283 patients with SSc admitted to Peking Union Medical College Hospital（PUMCH） from 1981 to 2009. A retrospective analysis was carried out. Results In the 283 patients, 253（89.4%） were female. The mean age at onset was 35.9 ± 12.6 years and mean disease duration 4.3 ± 4.5 years. There were 125 （44.2%） patients with diffuse SSc （dcSSc） and 158 （55.8%） with limited cutaneous SSc（lcSSc）. Of all the patients, 96.8% were positive for ANA, 54.4% for anti-Scl-70 antibodies, 6.4% for anticentromere antibodies（ACA）, 23.7% for anti-ribonucleoprotein （RNP） antibodies, 7.1% for anti-Sm antibodies, 25.1% for anti-SSA antibodies, 7.1% for anti-SSB antibodies, and 1.1% for anti-Jo-1 antibodies. No patients were positive for anti-rRNP antibodies. Only one patient was positive for both anti-Scl-70 antibodies and ACA. The positivity rate of ACA in patients with lcSSc was higher than that in those with dcSSc （P < 0.05）. Conclusion The detection of antinuclear antibodies is helpful for the diagnosis, classification, prognosis evaluation and management of SSc.

Key words: Scleroderma, systemic, Antibodies, antinuclear, Retrospective studies